文献类型：期刊文献

英文题名：Facile Synthesis of High Molecular Weight Polypeptides via Fast and Moisture Insensitive Polymerization of α-Amino Acid N-Carboxyanhydrides

作者：Wu, Yue-Ming[1];Zhang, Wei-Wei[1,3];Zhou, Rui-Yi[1,3];Chen, Qi[1,3];Xie, Chen-Yu[1,3];Xiang, Heng-Xue[2];Sun, Bin[2];Zhu, Mei-Fang[2];Liu, Run-Hui[1,3]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]Donghua Univ, Coll Mat Sci & Engn, State Key Lab Modificat Chem Fibers & Polymer Mat, Shanghai 201620, Peoples R China;[3]East China Univ Sci & Technol, Key Lab Specially Funct Polymer Mat & Related Tec, Minist Educ,Sch Mat Sci & Engn, Key Lab Ultrafine Mat,Res Ctr Biomed Mat, Shanghai 200237, Peoples R China

年份：2020

卷号：38

期号：10

起止页码：1131

外文期刊名：CHINESE JOURNAL OF POLYMER SCIENCE

收录：;EI(收录号：20212810632780);WOS:【SCI-EXPANDED(收录号:WOS:000554421700002)】；

基金：This work was financially supported by the National Natural Science Foundation of China (Nos. 21774031 and 21861162010), the National Key Research and Development Program of China (No. 2016YFC1100401), Research Program of State Key Laboratory of Bioreactor Engineering, State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Donghua University, the Fundamental Research Funds for the Central Universities (Nos. 22221818014 and 50321041917001). The authors also thank Research Center of Analysis and Test of East China University of Science and Technology for the help on the characterization.

语种：英文

外文关键词：NCA polymerization; Polypeptide; Open vessel; Fast polymerization; HighM(w)

摘要：Polypeptides have been widely utilized in the fields of biomaterials and biomedicine. Ever sinceN-carboxyanhydride (NCA) was reported by Hermann Leuchs in 1906, ring-opening polymerization of NCAs has been extensively used to prepare polypeptides. Despite continuous innovations, it is still challenging to synthesize polypeptides in high molecular weight efficiently. To address this challenge, we developed KHMDS/NaHMDS initiated fast NCA polymerization that is also moisture tolerant, open-flask amenable and terminal tunable. This NCA polymerization was able to proceed in most common solvents and meet the solubility requirement of variable NCA monomers and corresponding polypeptides. KHMDS can initiate gamma-benzyl-L-glutamate-N-carboxyanhydride (BLG NCA) polymerization in a reaction rate 92 times faster than does hexylamine and 80 times faster than does triethylamine. This NCA polymerization also demonstrated easy and fast synthesis of gram-scale long chain polypeptides in an open flask.