文献类型：期刊文献

英文题名：Ruthenium Complexes as Promising Candidates against Lung Cancer

作者：Sun, Qi[1];Li, Yingsi[1];Shi, Hongdong[2];Wang, Yi[3];Zhang, Jitian[4];Zhang, Qianling[2]

机构：[1]Shenzhen Univ, Hlth Sci Ctr, Int Canc Ctr,Dept Pharmacol, Guangdong Key Lab Genome Stabil & Dis Prevent, Shenzhen 518060, Peoples R China;[2]Shenzhen Univ, Coll Chem & Environm Engn, Shenzhen 518060, Peoples R China;[3]East China Univ Sci & Technol, Sch Chem & Mol Engn, Key Lab Adv Mat MOE, Shanghai 200237, Peoples R China;[4]Univ Hong Kong, Shenzhen Hosp, Dept Surg, Haiyuan 1st Rd, Shenzhen 518053, Peoples R China

年份：2021

卷号：26

期号：15

外文期刊名：MOLECULES

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000682176900001)】；

基金：This research was funded by the National Natural Science Foundation of China (21877103, 81602344, 21907069, 81802662), the Project of Natural Science Foundation of Guangdong Province (2019A1515011958), ShenzhenScienceandTechnologyInnovationCommission(GrantNo. KQJSCX20170331104516), SZU Medical Young Scientists Program (Grant No. 71201-000001). Medical Science and Technology Research Foundation of Guangdong Province (Grant No. A2019475).

语种：英文

外文关键词：Ruthenium complexes; lung cancer

摘要：Lung cancer is one of the most common malignancies with the highest mortality rate and the second-highest incidence rate after breast cancer, posing a serious threat to human health. The accidental discovery of the antitumor properties of cisplatin in the early 1960s aroused a growing interest in metal-based compounds for cancer treatment. However, the clinical application of cisplatin is limited by serious side effects and drug resistance. Therefore, other transition metal complexes have been developed for the treatment of different malignant cancers. Among them, Ru(II/III)-based complexes have emerged as promising anticancer drug candidates due to their potential anticancer properties and selective cytotoxic activity. In this review, we summarized the latest developments of Ru(II/III) complexes against lung cancer, focusing mainly on the mechanisms of their biological activities, including induction of apoptosis, necroptosis, autophagy, cell cycle arrest, inhibition of cell proliferation, and invasion and metastasis of lung cancer cells.