文献类型：期刊文献

英文题名：Evaluation of the cytotoxic effects of glyphosate herbicides in human liver, lung, and nerve

作者：Hao, Youwu[1];Zhang, Yang[1];Ni, Hongfei[1];Gao, Jufang[2];Yang, Yun[1];Xu, Wenping[1];Tao, Liming[1]

机构：[1]East China Univ Sci & Technol, Shanghai Key Lab Chem Biol, Sch Pharm, Shanghai 200237, Peoples R China;[2]Shanghai Normal Univ, Coll Life Sci, Shanghai, Peoples R China

年份：2019

卷号：54

期号：9

起止页码：737

外文期刊名：JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART B-PESTICIDES FOOD CONTAMINANTS AND AGRICULTURAL WASTES

收录：;EI(收录号：20192707129100);WOS:【SCI-EXPANDED(收录号:WOS:000472962000001)】；

基金：This work was financial supported by Shanghai Sailing Program (No. 19YF1411100), and Innovation Program of Shanghai Municipal Education Commission (No. 201701070002E00037).

语种：英文

外文关键词：Cytotoxicity; ethoxylated formulant; glyphosate herbicide; human health; pesticide

摘要：Glyphosate-based herbicides are broad-spectrum pesticides widely used in the world, which is considered a highly safe pesticide due to their target specificity, but recently, there has been an ongoing controversy regarding their carcinogenicity and possible side effects of glyphosate on human health. Commercial glyphosate-based herbicides (GBHs) consist of declared active ingredient (glyphosate salts) and a number of formulants such as ethoxylated formulants (4130 (R), 3780 (R), and A-178 (R)). The aim of our study is to investigate whether the toxicity of GBHs is related to formulants. The effects of GBHs on human health were studied at the cellular level based on their toxicity to liver, lungs and nerve tissue. The inhibitory toxicity to cell viability by GBHs was examined with cell-based systems using three human cell lines: HepG2, A549, and SH-SY5Y. Data obtained showed that all tested ethoxylated formulants and their mixtures with declared active ingredient glyphosate isopropylamine salt (GP) have significant inhibitory effect on cell proliferation, while the declared active ingredient has no significant toxicity. Our study demonstrates that the toxic effect of GBH is primarily due to the use of formulants. This result suggests that GP is relatively safe and a new approach for the assessment of toxicity should be made.