文献类型：期刊文献

英文题名：Well-Defined Poly(ethylene glycol) Hydrogels with Enhanced Mechanical Performance Prepared by Thermally Induced Copper-Catalyzed Azide-Alkyne Cycloaddition

作者：Li, Ke Wen[1];Cen, Lian[2,3];Zhou, Chao[1];Zhang, Ao Kai;Yao, Fang[1];Tan, Lin Hua[2];Xu, Li Qun[4];Fu, Guo Dong[1]

机构：[1]Southeast Univ, Sch Chem & Chem Engn, Nanjing 211189, Jiangsu, Peoples R China;[2]East China Univ Sci & Technol, Sch Chem Engn, Dept Prod Engn, Shanghai Key Lab Multiphase Mat Chem Engn, Shanghai 200237, Peoples R China;[3]Natl Tissue Engn Ctr China, Shanghai 200241, Peoples R China;[4]Southwest Univ, Fac Mat & Energy, Inst Clean Energy & Adv Mat, Chongqing 400715, Peoples R China

年份：2016

卷号：301

期号：11

起止页码：1374

外文期刊名：MACROMOLECULAR MATERIALS AND ENGINEERING

收录：;EI(收录号：20163002643196);WOS:【SCI-EXPANDED(收录号:WOS:000386924000012)】；

基金：This work was supported by National Natural Science Foundation of China under the Grant Nos. 21274020, 21074022, 21504072, and 21304019. This work was also supported by the Key Laboratory of Environmental Medicine Engineering of Ministry of Education (Southeast University), National "973" Project Foundation of China (Grant No. 2010CB944804), and "the Fundamental Research Funds for the Central Universities."

语种：英文

外文关键词：biocompatibility; hydrogels; mechanical properties; poly(ethylene glycol); thermally induced CuAAC

摘要：Poly(ethylene glycol) (PEG)-based hydrogels have attracted increasing attention in recent years due to their good biocompatibility and low cost. However, the PEG-based hydrogels prepared by traditional methods exhibit a poor machinability due to their disordered network structure. Herein, the preparation of well-defined PEG-based hydrogel via a facile thermally induced copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction is demonstrated. To accomplish this, thermochemically reduced Cu(I) catalyst is adopted to trigger "click" cross-linking, resulting in a well-defined PEG network. The as-synthesized PEG-based hydrogel exhibits good mechanical performance with a tensile strength of 2.51 MPa, which is higher than the traditional PEG-based hydrogels prepared from CuSO4/NaSac-mediated or CuBr/ligand-catalyzed CuAAC. Moreover, in vitro cytotoxicity and in vivo porcine subcutaneous implantation tests demonstrate that the as-synthesized PEG-based hydrogel has a good biocompatibility and low toxicity, making it a promising candidate for the applications in biomedical devices and tissue engineering.