文献类型：期刊文献

英文题名：Imaging of Colorectal Cancers Using Activatable Nanoprobes with Second Near-Infrared Window Emission

作者：Xu, Ge[1,2];Yan, Qinglong[3,4];Lv, Xiaoguang[5];Zhu, Ying[3,4];Xin, Kai[1,2];Shi, Ben[1,2];Wang, Rongchen[1,2];Chen, Jian[1,2];Gao, Wei[1,2];Shi, Ping[5];Fan, Chunhai[3,4];Zhao, Chunchang[1,2];Tian, He[1,2]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Chem & Mol Engn, Inst Fine Chem, Shanghai 200237, Peoples R China;[3]Chinese Acad Sci, Shanghai Inst Appl Phys, Div Phys Biol, Shanghai 201800, Peoples R China;[4]Chinese Acad Sci, Shanghai Inst Appl Phys, Bioimaging Ctr, Shanghai 201800, Peoples R China;[5]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

年份：2018

卷号：57

期号：14

起止页码：3626

外文期刊名：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

收录：;EI(收录号：20180904849453);WOS:【SCI-EXPANDED(收录号:WOS:000428350100013)】；

基金：We gratefully acknowledge the financial support by the National Science Foundation of China (grant numbers 21672062, 21421004, 11675251, 21390414), the Programme of Introducing Talents of Discipline to Universities (B16017), National Key R&D Program of China (2016YFA0201200, 2016YFA0400900), and the Key Research Program of Frontier Sciences, CAS (Grant NO. QYZDJ-SSW-SLH031).

语种：英文

外文关键词：colon cancer; fluorescence; invivo imaging; nanoprobes; second near-infrared window

摘要：Fluorescent probes in the second near-infrared window (NIR-II) allow high-resolution bioimaging with deep-tissue penetration. However, existing NIR-II materials often have poor signal-to-background ratios because of the lack of target specificity. Herein, an activatable NIR-II nanoprobe for visualizing colorectal cancers was devised. This designed probe displays H2S-activated ratiometric fluorescence and light-up NIR-II emission at 900-1300nm. By using this activatable and target specific probe for deep-tissue imaging of H2S-rich colon cancer cells, accurate identification of colorectal tumors in animal models were performed. It is anticipated that the development of activatable NIR-II probes will find widespread applications in biological and clinical systems.