文献类型：期刊文献

英文题名：Environmentally Friendly and Highly Efficient Co(OAc)2-Catalyzed Aerobic Oxidation to Access 2,6-Di-Electron-Donating Group Substituted 4-Hydroxybenzaldehydes

作者：Jiang, Jian-An[1];Du, Jia-Lei[1];Zhang, Zhong-Nan[1];Zhai, Jiao-Jiao[1];Ji, Ya-Fei[1]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China

年份：2014

卷号：44

期号：10

起止页码：1430

外文期刊名：SYNTHETIC COMMUNICATIONS

收录：;EI(收录号：20242616482420);WOS:【SCI-EXPANDED(收录号:WOS:000335119700005)，CCR-EXPANDED(收录号:WOS:000335119700005)】；

基金：We gratefully acknowledge the National Natural Science Foundation of China (Project No. 21176074) for financial support.

语种：英文

外文关键词：oxyfunctionalization; ethylene glycol; Aerobic oxidation; 4-hydroxybenzaldehydes; Co(OAc)2

摘要：A highly efficient and green aerobic oxidation has been developed for selectively preparing a series of valuable 2,6-dialkyl-, dialkoxyl-, and alkoxylalkyl-substituted 4-hydroxybenzaldehydes from corresponding 4-cresols in good to excellent yields, using a catalytic system of Co(OAc)(2)center dot 4H(2)O (1.0mol%)-NaOH (1.0 equiv)-O-2 (1.0atm) in aqueous ethylene glycol (EG/H2O=20/1, v/v) at 50 degrees C. Furthermore, a plausible mechanism was proposed for the direct oxyfunctionalization of the aromatic methyl group into the aldehyde group.