文献类型：期刊文献

英文题名：Photothermal Ring Integrated Intraocular Lens for High-Efficient Eye Disease Treatment

作者：Lin, Yao-Xin[1];Hu, Xue-Feng[2];Zhao, Yang[3];Gao, Yu-Juan[1];Yang, Chao[1];Qiao, Sheng-Lin[1];Wang, Yi[1];Yang, Pei-Pei[1];Yan, Jiao[4];Sui, Xin-Ce[5];Qiao, Zeng-Ying[1];Li, Li-Li[1];Xie, Jiang-Bing[5];Zhu, Si-Quan[3];Wu, Xiao-Chun[4];Li, Yongsheng[2];Wang, Lei[1];Wang, Hao[1]

机构：[1]Natl Ctr Nanosci & Technol NCNST, CAS Key Lab Biol Effects Nanomat & Nanosafety, CAS Ctr Excellence Nanosci, 11 Beiyitiao, Beijing 100190, Peoples R China;[2]East China Univ Sci & Technol, Sch Mat Sci & Engn, Key Lab Ultrafine Mat, Lab Low Dimens Mat Chem,Minist Educ, Shanghai 200237, Peoples R China;[3]Capital Med Univ, Beijing Tongren Eye Ctr, Beijing 100730, Peoples R China;[4]Natl Ctr Nanosci & Technol, CAS Key Lab Standardizat & Measurement Nanotechno, Beijing 100190, Peoples R China;[5]Eyebright Med Technol Co Ltd, Bldg 6,37 Chaoqian Rd, Beijing 102200, Peoples R China

年份：2017

卷号：29

期号：34

外文期刊名：ADVANCED MATERIALS

收录：;EI(收录号：20172903959614);WOS:【SCI-EXPANDED(收录号:WOS:000409448300030)】；

基金：Y.-X.L., X.-F.H., and Y.Z. contributed equally to this work. This work was supported by the Program of Beijing Municipal Science and Technology (Grant No. Z141100000214008), National Basic Research Program of China (973 Program, Grant No. 2013CB932701), and the National Natural Science Foundation of China (Grant Nos. 51573031, 21373726, 21303723, and 51303036). All animal experiments were performed complying with the NIH guidelines for the care and use of laboratory animals of National Center for Nanoscience and Technology Animal Study Committee's requirements and according to the protocol approved by the Institutional Animal Care.

语种：英文

外文关键词：gold nanorods; nanoparticles; photothermal; posterior capsule opacification

摘要：Posterior capsule opacification (PCO) is the most common complication after cataract surgery. So far, the only method for PCO treatment is the precisely focused laser surgery. However, it causes severe complications such as physical damages and neuron impairments. Here, a nanostructured photothermal ring integrated intraocular lens (Nano-IOLs) is reported, in which the rim of commercially available IOLs (C-IOLs) is decorated with silica coated Au nanorods (Au@SiO2), for high-efficient prevention of PCO after cataract surgery. The Nano-IOLs is capable of eliminating the residual lens epithelial cells (LECs) around Nano-IOLs under mild laser treatment and block the formation of disordered LECs fibrosis, which eventually leads to the loss of vision. The Nano-IOLs shows good biocompatibility as well as extraordinary region-confined photothermal effect. In vivo studies reveal that PCO occurrence in rabbit models is about 30%-40% by using Nano-IOLs, which is significantly lower than the control group that treated with C-IOLs (100% PCO occurrence) 30 d postsurgery. To the best of our knowledge, it is the first example to integrate nanotechnology with intraocular implants aiming to clinically relevant PCO. Our findings indicate that spatial controllability of photothermal effect from nanomaterials may provide a unique way to intervene the PCO-induced loss of vision.