文献类型：期刊文献

英文题名：Injectable, Anti-Collapse, Highly Adhesive and Plasticity Bioactive Artificial Bone Promotes Bone Regeneration by Moderating Oxidative Stress in Osteoporotic Bone Defect

作者：Huang, Lei[1]; Zhang, Shihao[2]; Bian, Mengxuan[1]; Xiao, Lan[3]; Chen, Weisin[1]; Wang, Jiayi[1]; Lu, Shunyi[1]; Xiang, Xingdong[1]; Li, Yulin[2]; Jiang, Libo[1]; Zhang, Jian[1]

机构：[1] Department of Orthopedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China; [2] The Key Laboratory for Ultrafine Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Engineering Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, 200237, China; [3] Centre for Biomedical Technologies, School of Mechanical, Medical and Process Engineering, Queensland University of Technology, Brisbane, 4059, Australia

年份：2023

外文期刊名：SSRN

收录：EI(收录号：20230443915)

语种：英文

外文关键词：Adhesives - Biocompatibility - Bone - Defects - Lactic acid - Nanoparticles - Selenium - Transmission control protocol

摘要：The treatment of osteoporotic bone defect remains a big clinical challenge because osteoporosis (OP) is associated with oxidative stress and high levels of reactive oxygen species (ROS), a condition detrimental for bone formation. Anti-oxidative nanomaterials such as selenium nanoparticles (SeNPs) have positive effect on osteogenesis owing to their pleiotropic pharmacological activity which can exert anti-oxidative stress functions to prevent bone loss and facilitate bone regeneration in OP. In the current study a strategy of one-pot method by introducing Poly (lactic acid-carbonate) (PDT) and β-Tricalcium Phosphate (β-TCP) with SeNPs, is developed to prepare an injectable, anti-collapse, shape-adaptive and highly adhesive artificial bone material (PDT-TCP-SE). The PDT-TCP-SE artificial bone exhibits sufficient adhesion in biological microenvironments and good biocompatibility, osteogenic effect, angiogenic effect and anti-inflammatory as well as anti-oxidative effect in vitro and in vivo. Moreover, the PDT-TCP-SE can protect BMSCs from erastin-induced ferroptosis through the Sirt1/Nrf2/GPX4 antioxidant pathway, which, in together, demonstrated the artificial bone as a novel biomaterial with potential clinical application for the future treatment of osteoporotic bone defects. ? 2023, The Authors. All rights reserved.