文献类型：期刊文献

中文题名：2H－4，9－二甲基呋喃并［2′，3′∶5，6］萘并［1，2－b］吡喃－2－酮的合成、光谱及DNA嵌入活性

英文题名：Synthesis,Spectra and DNA Intercalation of 2H-4,9-Dimethylfuro[2′,3′:5,6] naphtho [1,2-b] pyron-2-one

作者：陶志福[1];钱旭红[1];唐军[1];陈馥衡[1]

机构：[1]华东理工大学药物化工研究所,北京农业大学应用化学系

年份：1996

卷号：13

期号：4

起止页码：34

中文期刊名：应用化学

外文期刊名：Chinese Journal of Applied Chemistry

收录：北大核心:【北大核心1992】；CSCD:【CSCD2011_2012】；

基金：国家自然科学基金;国家教委重点博士点基金;优秀年轻教师基金

语种：中文

中文关键词：萘并吡喃酮;DNA;嵌入;光谱;荧光淬灭

外文关键词：naphthopyrones;DNA intercalation activity; synthesis;spectrum

摘要：以萘并吡喃酮为原料，通过３种方法合成了标题化合物，其结构经１￣ＨＮＭＲ，ＩＲ，ＭＳ及元素分析确证，并考察对小牛胸腺ＤＮＡ的嵌入活性。
The title compound was synthesized by three methods from naphthopyrone. The structures of this compound and its precursors were fully characterized by 1H NMR, MS, IR and elemental analysis.Its DNA-intercalative activity was investigated in DMSO-Tris HCl system by fluorescence quenching technique and the apparent Scatchard binding constant was estimated. Results showed that it efficiently intercalated into DNA.The spectral properties and DNA-intercalative activity have been compared with those of its analogues.