文献类型：期刊文献

英文题名：Building Biomedical Materials using Photochemical Bond Cleavage

作者：Bao, Chunyan[1];Zhu, Linyong[1];Lin, Qiuning[1];Tian, He[1]

机构：[1]E China Univ Sci & Technol, Inst Fine Chem, Key Lab Adv Mat, Shanghai 200237, Peoples R China

年份：2015

卷号：27

期号：10

起止页码：1647

外文期刊名：ADVANCED MATERIALS

收录：;EI(收录号：20150700506384);WOS:【SCI-EXPANDED(收录号:WOS:000350754100001)】；

基金：This work was supported by NSFC/China (21173078, 21373084, 51273064), Innovation Program of Shanghai Municipal Education Commission, Fundamental Research Funds for the Central University, National Basic Research 973 Program (2011CB8068400). Thanks are extended to all co-workers working on phototrigger based materials in the authors' lab.

语种：英文

外文关键词：Interfaces (materials) - Medical applications - Photolysis

摘要：Light can be used as an external trigger to precisely determine where and when a process is initiated as well as how much of the process is being consumed. Phototriggers are a type of photoresponsive functional group that undergo an irreversible photolysis reaction by selectively breaking a chemical bond, enabling three fundamental functions: the photoactivation of fluorescent and bioactive molecules; the photocleavable degradation of macromolecular materials; and the photorelease of drugs, active groups, or surface charges from carriers and interfaces. With the expanded applications of light-controlled technology, particularly in living systems, new challenges and improvements of phototriggers are required to fulfill the demands for better sensitivity, faster kinetics, and more-demanding biomedical applications. Here, improvements to several conventional phototriggers are highlighted, and their notable, representative biomedical applications and their challenges are discussed.