文献类型：期刊文献

中文题名：玉米蛋白/吐温-20复合纳米颗粒对姜黄素的包载作用

英文题名：Effect of Zein/Tween-20 Composite Nanoparticles on the Properties of Encapsulated Curcumin

作者：褚翔宇[1];王小永[1]

机构：[1]华东理工大学化学与分子工程学院,上海200237

年份：2018

卷号：81

期号：7

起止页码：625

中文期刊名：化学通报

外文期刊名：Chemistry

收录：CSTPCD;;Scopus;北大核心:【北大核心2017】；CSCD:【CSCD2017_2018】；

基金：国家自然科学基金项目(21573071)资助

语种：中文

中文关键词：玉米蛋白;吐温-20;姜黄素;包封率;稳定性;荧光光谱

外文关键词：Zein;Tween-20;Curcumin;Encapsulation efficiency;Stability;Fluorescence

摘要：本文采用反溶剂沉淀法制备了玉米蛋白/吐温-20复合纳米颗粒。通过测定玉米蛋白/吐温-20复合纳米颗粒对姜黄素的包封率、稳定性及荧光光谱性质,考察了不同浓度吐温-20对玉米蛋白/吐温-20复合纳米颗粒包载姜黄素的影响规律。相比玉米蛋白纳米颗粒,玉米蛋白/吐温-20复合纳米颗粒能够显著提高姜黄素的包封率、稳定性、荧光发射光谱强度和各向异性。这些结果说明姜黄素通过疏水作用缔合于玉米蛋白/吐温-20复合纳米颗粒的疏水微区。吐温-20作为稳定剂不仅有助于生成粒径较小的玉米蛋白/吐温-20复合纳米颗粒,而且吐温-20与玉米蛋白的结合能够为姜黄素提供更适合的疏水缔合环境。
In this paper,zein/Tween-20 composite nanoparticles were prepared by anti-solvent precipitation.By measuring the encapsulation efficiency,stability,and fluorescence properties of curcumin in zein/Tween-20 composite nanoparticles,the influence of Tween-20 concentration on the interaction between zein/Tween-20 composite nanoparticles and curcumin was investigated. Compared to zein nanoparticles,zein/Tween-20 composite nanoparticles can significantly increase the encapsulation efficiency,stability,fluorescence emission intensity,and anisotropy of curcumin. These results indicate that curcumin is bound in hydrophobic domains of zein/Tween-20 composite nanoparticles via hydrophobic interactions. Tween-20 as a stabilizer not only helps to produce smaller zein/Tween-20 composite nanoparticles,but also provides a more suitable hydrophobic binding environment for curcumin.