文献类型：期刊文献

英文题名：Effect of Constituents from Fructus Aurantii Immaturus and Radix Paeoniae Alba on Gastrointestinal Movement

作者：Fang, Yi-Shi[1,2];Shan, Dong-Mei[1,2];Liu, Jian-Wen[1,2];Xu, Wen[1,2];Li, Chang-Long[1,2];Wu, Hong-Zhong[1,2];Ji, Guang[3]

机构：[1]E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China;[3]Shanghai Univ Tradit Chinese Med, Longhua Hosp, Lab Liver Dis, Shanghai 200032, Peoples R China

年份：2009

卷号：75

期号：1

起止页码：24

外文期刊名：PLANTA MEDICA

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000263032200005)】；

基金：This study was supported by a grant from the Science and Technology Commission of Shanghai Municipality (No. 05DZ19733) and was also funded by 111 Plan (Ministry of Education of the People's Republic of China).

语种：英文

外文关键词：Citrus aurantium L.; Rutaceae; Paeonia lactiflora Pall; Paeoniaceae; gastrointestinal movement

摘要：Fructus Aurantii Immaturus and Radix Paeoniae Alba Powder (FPP) is a popular Chinese herbal prescription. The combination of Fructus Aurantii Immaturus and Radix Paeoniae Alba has been used to treat gastrointestinal disorders for hundreds of years. To our interest, this combination shows a bilateral effect on gastrointestinal peristalsis. Our present study was focused on the bilateral role of this combination on the gastrointestinal tract. The effective constituents and mechanisms were explored. Six monomer constituents from Radix Paeoniae Alba and Fructus Aurantii Immaturus were screened by intestinal transit assay. The bilateral roles of three effective constituents were authenticated by gastric emptying assay, and the combination of three constituents showed a bilateral effect. Then, the mediating receptors and the role of NO and NF-kappa B p65 were examined to determine the mechanism involved. The overall results suggest that the major effective constituents of this combination are synephrine, hesperidin and paeoniflorin. Synephrine inhibits the gastrointestinal movement, while hesperidin stimulates it. Paeoniflorin shows different effects on intestinal and gastric activity. The effect of synephrine relies on the a-adrenergic receptor, and the effect of hesperidin is mediated via the H1 histamine receptor. The regulation of hesperidin and synephrine on NF-kappa B p65 translocation and NO production through the a-receptor and the HI receptor, respectively, is involved in the bilateral effect of the Fructus Aurantii Immaturus-Radix Paeoniae Alba combination.