文献类型：期刊文献

中文题名：中药郁金香总黄酮的抗皮肤光老化活性评价及机制分析

英文题名：Anti-Skin Photoaging Activity and Mechanism Analysis of Total Flavonoids from the Chinese Herb Tulip

作者：叶佳丰[1];曹家敏[1];李薇[1];马悦文[1];王春丽[1]

机构：[1]华东理工大学药学院、制药工程与过程化学教育部工程研究中心、上海市新药设计重点实验室,上海200237

年份：2025

卷号：27

期号：7

起止页码：2000

中文期刊名：世界科学技术-中医药现代化

外文期刊名：Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

收录：;北大核心:【北大核心2023】；

基金：中华人民共和国科学技术部国家重大科技专项(2018ZX09735002):中药组分信息数据库,负责人:马磊。

语种：中文

中文关键词：中药郁金香;黄酮;皮肤光老化;网络药理学;分子模拟

外文关键词：The Chinese herb tulip;Flavonoid;Skin photoaging;Network pharmacology;Molecular simulation

摘要：目的评估中药郁金香总黄酮(Total flavonoids,TFT)的抗皮肤光老化活性,并初步分析其抗皮肤光老化的机制。方法采用UVB诱导的光老化小鼠模型评估TFT的抗皮肤光老化作用;采用网络药理学方法对TFT抗皮肤光老化的作用机制进行初步分析。此外,通过分子模拟预测活性成分与靶蛋白之间的相互作用。结果TFT的处理可以有效改善UVB诱导的光老化小鼠的皮肤状态;TFT抗皮肤光老化的作用机制可能涉及对转录因子NF-κB、AP-1相关基因、SASPs转录和MMPs活性的调节。结论TFT是一种有效抗皮肤光老化的成分,值得进一步研究和开发。
Objective To assess the anti-skin photoaging properties of total flavonoids(TFT)extracted from the Chinese herb tulip,a preliminary analysis of its mechanism in combating skin photoaging were conducted.Methods UVBinduced photoaging mouse model was used to assess the anti-skin photoaging effects of TFT.A network pharmacology approach was used to conduct a preliminary analysis of TFT′s mechanism of action against skin photoaging.Furthermore,molecular simulation was employed to predict the interactions between the active ingredients and target proteins.Results Treatment with TFT effectively improved skin condition in UVB-induced photoaging mice.The mechanism of action of TFT against skin photoaging likely involved the regulation of transcription factors such as NF-κB and AP-1,modulation of SASPs transcription,and inhibition of MMPs activity.Conclusion TFT is an effective antiskin photoaging ingredient that deserves further research and development.