文献类型：期刊文献

英文题名：A FRET-based dual-channel turn-on fluorescence probe for the detection of Hg2+ in living cells

作者：Yuan, Xiao[1,2];Leng, Tao-Hua[3];Guo, Zhi-Qian[1,2];Wang, Cheng-Yun[1,2];Li, Ji-Zhen[1,2];Yang, Wei-Wei[4];Zhu, Wei-Hong[1,2]

机构：[1]East China Univ Sci & Technol, Key Lab Adv Mat, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Inst Fine Chem, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China;[3]Shanghai Inst Qual Inspect & Tech Res, Natl Food Qual Supervis & Inspect Ctr Shanghai, Shanghai 200233, Peoples R China;[4]East China Univ Sci & Technol, Sch Chem & Mol Engn, Dept Chem, Shanghai 200237, Peoples R China

年份：2019

卷号：161

起止页码：403

外文期刊名：DYES AND PIGMENTS

收录：;EI(收录号：20184105914687);WOS:【SCI-EXPANDED(收录号:WOS:000449241200049)】；

基金：The authors are grateful to financial support from the National Key Program of China (No. 2016YFA0200302) and Natural Science Foundation of Shanghai (16ZR1408000).

语种：英文

外文关键词：Naphthalimide; Mercury; Dual-channel; Lysosome-targeted; Cell imaging

摘要：Since the mercury ions are particularly toxic and they can cause severe harmful effects even at low concentration, searching for selective and sensitive probe to detect Hg2+ is of considerable significance. In this study, Rhodamine-naphthalimide conjugate (NRT) has been developed as a novel lysosome-targeted ratiometric Hg2+ probe. NRT exhibited calorimetric and dual-channel turn-on fluorescence responses toward Hg2+ and could be used to quantify the ion spiked in river water samples. Besides, the probe could also selectively stain lysosomes and sensitively visualize mercury ions in living cells by dual-channel imaging.