文献类型：期刊文献

中文题名：由间二氯苯合成2，4－二氟苯胺

英文题名：Synthesis of 2,4-Difluoroaniline from 1,3-Dichlorobenzene

作者：王东平[1];樊行雪[1];杨铁金[1];骆赞椿[1];朱文利[1]

机构：[1]华东理工大学化学工程系

年份：1996

卷号：22

期号：3

起止页码：255

中文期刊名：华东理工大学学报（自然科学版）

外文期刊名：Journal of East China University of Science and Technology

收录：CSTPCD;;国家哲学社会科学学术期刊数据库;Scopus;CSCD:【CSCD2011_2012】；

语种：中文

中文关键词：二氟苯胺;有机合成;还原;间二氯苯;合成

外文关键词：difluoroaniline;organic synthesis;nitration;fluorination;reduction

摘要：以间二氯苯为原料，经硝化、氟代及还原反应合成２，４－二氟苯胺。探索了各步反应的工艺条件，对提高收率难度较大的氟代反应，研究了使用季铵盐类相转移催化剂时原料配比、反应温度及时间与收率之间的关系，并得到了较好的结果。硝化反应收率达９７％，氟代７０％，还原８９％。与其它方法相比，产品总收率由２２％～５０％提高到６０％以上，从而使文题所示的合成路线成为技术、经济上可行的方法。
Difiuoroaniline was synthesised from l,3 dichlorobenzene as a starting material via nitration,fluorination and reduction,The suitable technological conditions were probed for each step of the reactions.Because it seemed hard to obtain high yields of the fluorination replacement reaction,the relations of the proportions of the raw materials,the reaction temperature and the reaction time to the yields were researched in the presence of a solid liquid phase transfer catalyst using orthogonal design method,Better results have been achieved in experiment.The yield of the nitration reaction was 97%,fluorination 70% and reduction 89%.As compared with the other methods of preparing 2,4-difluoroaniline,the overall yield has been increased from 22%～ 50% to 60% or more.Thus the topical method witch is feasible techno-economically proves the efficient one of preparing 2,4-difluoroaniline.