文献类型：期刊文献

中文题名：Synthesis and insecticidal bioactivities of 2,3-dihydroimidazo[1,2-a] pyridin-5(1H)-one derivatives

英文题名：Synthesis and insecticidal bioactivities of 2,3-dihydroimidazo[1,2-a] pyridin-5(1H)-one derivatives

作者：Letian Zhang[1];Kun Liu[1];Xusheng Shao[1];Zhong Li[1,2];Xiaoyong Xu[1,2]

机构：[1]Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology;[2]Shanghai Collaborative Innovation Center for Biomanufacturing Technology

年份：2019

卷号：30

期号：2

起止页码：340

中文期刊名：Chinese Chemical Letters

外文期刊名：中国化学快报（英文版）

收录：CSTPCD;;Scopus;CSCD:【CSCD2019_2020】；

基金：financial supported by the National Key Research Program of China(No. 2017YFD0200500);National Natural Science Foundation of China(No.21672061);supported by the Fundamental Research Funds for the Central Universities(No. 222201718004)

语种：英文

中文关键词：Reaction;selectivity;2,3-Dihydroimidazo[1,2-a]pyridin-5(1H)one;Bicyclic;pyridone;Insecticidal;activities;Acaricidal;activitiy

外文关键词：Reaction selectivity;2,3-Dihydroimidazo[1,2-a]pyridin-5(1H)one;Bicyclic pyridone;Insecticidal activities;Acaricidal activitiy

摘要：A novel synthesis of 2,3-dihydroimidazo[1,2-a]pyridin-5 (1H)-one 4 and its derivatives were described.Preliminary bioassays showed that some of the target compounds exhibited excellent insecticidal activities against brown planthopper (Nilaparvata lugens), cowpea aphids (Aphis craccivora) (4,5 a, 5 c, 5 g,5 h, 5 j, 5 r, 6 b, 6 e) and carmine spider mite (Tetranychus cinnabarinus (5 f, 5 s, 6 a) at 500 mg/L. Among them,compound 4 was still active against brown planthopper and cowpea aphids at 4 mg/L. The insecticidal activities were influenced by the types and position of the substituents, which provided guidance for the structure modifications.
A novel synthesis of 2,3-dihydroimidazo[1,2-a]pyridin-5 (1H)-one 4 and its derivatives were described.Preliminary bioassays showed that some of the target compounds exhibited excellent insecticidal activities against brown planthopper (Nilaparvata lugens), cowpea aphids (Aphis craccivora) (4,5 a, 5 c, 5 g,5 h, 5 j, 5 r, 6 b, 6 e) and carmine spider mite (Tetranychus cinnabarinus (5 f, 5 s, 6 a) at 500 mg/L. Among them,compound 4 was still active against brown planthopper and cowpea aphids at 4 mg/L. The insecticidal activities were influenced by the types and position of the substituents, which provided guidance for the structure modifications.