文献类型：期刊文献

英文题名：Scalable synthesis of methyl ent-isocopalate and its derivatives

作者：Hua, Si-Kai[1,2];Wang, Jing[1,2];Chen, Xi-Bo[1,2];Xu, Zhong-Yu[1];Zeng, Bu-Bing[1,2]

机构：[1]Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China

年份：2011

卷号：67

期号：6

起止页码：1142

外文期刊名：TETRAHEDRON

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000287286500012)，CCR-EXPANDED(收录号:WOS:000287286500012)】；

基金：We are grateful for the financial support by the national '863' Project of China (2006AA609Z447 and 2007AA02Z301), 111 Project (B07023), and Shanghai Foundation of Science and Technology (09JC1404200).

语种：英文

外文关键词：Methyl ent-isocopalate; (-)-Sclareol; Tricycle diterpene; Spongiane

摘要：An efficient and convenient synthetic route was developed to prepare the tricycle diterpene intermediates 1-3 starting from commercially available (-)-sclareol. This improved approach involving four-step reactions provides large-scale (30-40 g) methyl ent-isocopalate in 61% overall yield, which could supply sufficient material for the synthesis of marine natural products containing tricyclic diterpenes. Crown Copyright (C) 2010 Published by Elsevier Ltd. All rights reserved.