文献类型：期刊文献

英文题名：Recent advances in green multi-component reactions for heterocyclic compound construction

作者：Shen, Xinling[1,2];Hong, Gang[1,2,3];Wang, Limin[1,2]

机构：[1]East China Univ Sci & Technol, Key Lab Adv Mat, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Inst Fine Chem, 130 Meilong Rd, Shanghai 200237, Peoples R China;[3]Univ Penn, Dept Chem, Roy & Diana Vagelos Labs, Philadelphia, PA 19104 USA

年份：2025

卷号：23

期号：9

起止页码：2059

外文期刊名：ORGANIC & BIOMOLECULAR CHEMISTRY

收录：;EI(收录号：20250617805412);WOS:【SCI-EXPANDED(收录号:WOS:001409952500001)】；

基金：This research was financially supported by the National Natural Science Foundation of China (21772039, 21272069) and the Sinopec Seeding Program (ZC0607-0869), and we gratefully acknowledge financial support from the Central Universities and Science and Technology Commission of Shanghai Municipality (21DZ2305000) and the Fundamental Research Funds for the Central Universities (SLA13223001).

语种：英文

外文关键词：Addition reactions - Catalysis - Green Synthesis

摘要：Multi-component reactions (MCRs) are processes in which three or more reactants are introduced into one pot to obtain the final product with high atom efficiency, and in recent years, these have become a key strategy for advancing more sustainable processes in modern synthetic communities and the pharmaceutical industry. Meanwhile, minimizing the use of solvents, catalysts, time, reagents, and waste is essential during green chemical synthesis to reduce cost and environmental impact. Heterocycles are ubiquitous and have thus prompted the development of numerous methods for their synthesis. Among various strategies, MCRs represent one of the most promising routes for the synthesis of heterocyclic moieties such as quinolines, quinazolines, pyrimidines and imidazoles, which are widely recognized in nature and clinical evaluation. To promote greener syntheses, a significant body of literature detailing the synthesis of these biologically important compounds via environmentally friendly MCRs has emerged. This review focused on the recent advances in the green approach to preparing heterocyclic compounds via MCRs. These green approaches included photoredox catalysis, electrochemical activation, catalyst-free methods, and the use of water as the sole green solvent, reported between 2018 and 2024, highlighting their strengths and limitations. The synthesis of different types of heterocycles via green MCRs was covered. The substrate scope, reaction conditions, yields and mechanisms were also examined and discussed.