文献类型：期刊文献

英文题名：Practical Preparation of Infection-Resistant Biomedical Surfaces from Antimicrobial β-Peptide Polymers

作者：Qi, Fan[1];Qian, Yuxin[1];Shao, Ning[1];Zhou, Ruiyi[1];Zhang, Si[1];Lu, Ziyi[1];Zhou, Min[1];Xie, Jiayang[1];Wei, Ting[2];Yu, Qian[2];Liu, Runhui[1]

机构：[1]East China Univ Sci & Technol, Sch Mat Sci & Engn, Key Lab Ultrafine Mat,Minist Educ, State Key Lab Bioreactor Engn,Res Ctr Biomed Mat, Shanghai 200237, Peoples R China;[2]Soochow Univ, Coll Chem Chem Engn & Mat Sci, State & Local Joint Engn Lab Novel Funct Polymer, Suzhou 215123, Peoples R China

年份：2019

卷号：11

期号：21

起止页码：18907

外文期刊名：ACS APPLIED MATERIALS & INTERFACES

收录：;EI(收录号：20192407024266);WOS:【SCI-EXPANDED(收录号:WOS:000470034700003)】；

基金：This research was supported by the National Natural Science Foundation of China (no. 21574038, 21774031, 21861162010), the National Key Research and Development Program of China (2016YFC1100401), the National Natural Science Foundation of China for Innovative Research Groups (no. 51621002), the Natural Science Foundation of Shanghai (18ZR1410300), the "Eastern Scholar Professorship" from Shanghai local government (TP2014034), the national special fund for State Key Laboratory of Bioreactor Engineering (2060204), the Fundamental Research Funds for the Central Universities (22221818014), the authors also thank Research Center of Analysis and Test of East China University of Science and Technology for the help on the characterization.

语种：英文

外文关键词：beta-peptide polymer; host defense peptide; antimicrobial surface; MRSA; subcutaneous infection

摘要：Tackling microbial infection associated with biomaterial surfaces has been an urgent need. Synthetic beta-peptide polymers can mimic host defense peptides and have potent antimicrobial activities without driving the bacteria to develop antimicrobial resistance. Herein, we demonstrate a plasma surface activation-based practical beta-peptide polymer modification to prepare antimicrobial surfaces for biomedical materials such as thermoplastic polyurethane (TPU), polytetrafluoroethylene, polyvinyl pyrrolidone, polyvinyl chloride, and polydimethylsiloxane. The beta-peptide polymer modified surfaces demonstrated effective killing on drug-resistant Gram-positive and Gram-negative bacteria. The antibacterial function retained completely even after the beta-peptide polymer-modified surfaces were stored at ambient temperature for at least 2 months. Moreover, the optimum beta-peptide polymer (50:50 DM-Hex)-modified surfaces displayed no hemolysis and cytotoxicity. In vivo study using methicillin-resistant Staphylococcus aureus (MRSA)-pre-incubated TPU-50:50 DM-Hex surfaces for subcutaneous implantation revealed a 3.4-log reduction of MRSA cells after the implantation for 11 days at the surrounding tissue of implanted TPU sheet and significant suppression of infection, compared to bare TPU control. These results imply promising and practical applications of beta-peptide polymer tethering to prepare infection-resistant surfaces for biomedical materials and devices.