文献类型：期刊文献

中文题名：Injured bone-triggered osteokines secretion promotes diabetic wound healing

作者：Tong Shen[1,2];Kai Dai[2,3,4];Shuang Zhang[1,2];Jing Wang[1,2,4];Changsheng Liu[2,3,4]

机构：[1]State Key Laboratory of Bioreactor Engineering,East China University of Science and Technology,Shanghai,PR China;[2]Engineering Research Center for Biomedical Materials of the Ministry of Education,East China University of Science and Technology,Shanghai,PR China;[3]Key Laboratory for Ultrafine Materials of the Ministry of Education,East China University of Science and Technology,Shanghai,PR China;[4]Frontiers Science Center for Materiobiology and Dynamic Chemistry,East China University of Science and Technology,Shanghai,PR China

年份：2025

卷号：13

期号：6

起止页码：1449

中文期刊名：Bone Research

外文期刊名：骨研究(英文版)

基金：supported by the Key Program of the National Natural Science Foundation of China grants 32230059;the Basic Science Center Program T2288102,the National Natural Science Foundation of China grants 32301123;the Foundation of Frontiers Science Center for Materiobiology and Dynamic Chemistry JKVD1211002。

语种：英文

中文关键词：exert systemic effects;severe diabetic foot;bone injury;bone injury strategy;osteokines;diabetic wound healing;platelet derived growth factor bb;keratinocyte growth factor;

摘要：The treatment of severe diabetic foot remains a clinical challenge.While it is established that bone can exert systemic effects through the secretion of osteokines on other organs,whether this endocrine function can be harnessed to promote diabetic wound healing remains unexplored.Here,we investigate the impact of a bone injury strategy on diabetic wound healing,leveraging the body's innate regenerative capacity to stimulate osteokine release and influence remote skin wound repair.This study demonstrates that the tibial defect significantly accelerates ipsilateral diabetic foot skin wound healing.Mechanistically,we identify osteokines,platelet-derived growth factor-BB(PDGF-BB),as the key to initiating this process.Bone defect triggers a substantial release of PDGF-BB,which reaches the skin wound site via peripheral circulation.At the skin wound site,PDGF-BB mediates the secretion of keratinocyte growth factor(KGF)from fibroblasts via the PDGFRβsignaling pathway,thereby promoting the rapid reepithelialization of epidermal cells through a paracrine pathway.Additionally,elevated PDGF-BB levels enhance the regeneration of CD31^(h i)Emcn^(h i)blood vessels within the wound.Importantly,we demonstrate the therapeutic potential of osteokines by showing that a collagen hydrogel loaded with osteokines promotes wound healing in diabetic mice.Our findings reveal a clear link between bone and skin wound healing,providing a therapeutic inspiration for chronic wounds that are difficult to treat locally.