文献类型：期刊文献

英文题名：Advances and prospects in metabolic engineering of Zymomonas mobilis

作者：Wang, Xia[1];He, Qiaoning[1];Yang, Yongfu[1];Wang, Jingwen[1];Haning, Katie[2];Hu, Yun[1];Wu, Bo[3];He, Mingxiong[3];Zhang, Yaoping[4];Bao, Jie[5];Contreras, Lydia M.[2];Yang, Shihui[1]

机构：[1]Hubei Univ, Hubei Collaborat Innovat Ctr Green Transformat Bi, Environm Microbial Technol Ctr Hubei Prov, Hubei Key Lab Ind Biotechnol,Coll Life Sci, Wuhan 430062, Hubei, Peoples R China;[2]Univ Texas Austin, Dept Chem Engn, Inst Cellular & Mol Biol, Cockrell Sch Engn, Austin, TX 78712 USA;[3]Minist Agr, Biomass Energy Technol Res Ctr, Key Lab Dev & Applicat Rural Renewable Energy, Biogas Inst, South Renmin Rd, Chengdu 610041, Sichuan, Peoples R China;[4]Univ Wisconsin, DOE, GLBRC, Madison, WI USA;[5]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2018

卷号：50

起止页码：57

外文期刊名：METABOLIC ENGINEERING

收录：;EI(收录号：20181605014735);WOS:【SCI-EXPANDED(收录号:WOS:000450620100005)】；

基金：LMC and KH would like to acknowledge the funding of National Science Foundation Career Award (CBET-1254754) and Welch Foundation (Grant F-1756) to LMC, and Graduate Research Fellowship (DGE-1610403) to KH. YZ is funded by the DOE Great Lakes Bioenergy Research Center (DOE Office of Science BER DE-FC02-07ER64494 and DE-SC0018409).

语种：英文

外文关键词：Zymomonas mobilis; Industrial chassis; Biorefinery; Biochemical production; Metabolic engineering; Synthetic biology

摘要：Biorefinery of biomass-based biofuels and biochemicals by microorganisms is a competitive alternative of traditional petroleum refineries. Zymomonas mobilis is a natural ethanologen with many desirable characteristics, which makes it an ideal industrial microbial biocatalyst for commercial production of desirable bioproducts through metabolic engineering. In this review, we summarize the metabolic engineering progress achieved in Z. mobilis to expand its substrate and product ranges as well as to enhance its robustness against stressful conditions such as inhibitory compounds within the lignocellulosic hydrolysates and slurries. We also discuss a few metabolic engineering strategies that can be applied in Z. mobilis to further develop it as a robust workhorse for economic lignocellulosic bioproducts. In addition, we briefly review the progress of metabolic engineering in Z. mobilis related to the classical synthetic biology cycle of "Design-Build-Test-Learn", as well as the progress and potential to develop Z. mobilis as a model chassis for biorefinery practices in the synthetic biology era.