文献类型：期刊文献

英文题名：Spatiotemporally Controllable and Cytocompatible Approach Builds 3D Cell Culture Matrix by Photo-Uncaged-Thiol Michael Addition Reaction

作者：Liu, Zhenzhen[1];Lin, Qiuning[1];Sun, Yun[2,3];Liu, Tao[1];Bao, Chunyan[1];Li, Fuyou[2,3];Zhu, Linyong[1]

机构：[1]E China Univ Sci & Technol, Key Lab Adv Mat, Inst Fine Chem, Shanghai 200237, Peoples R China;[2]Fudan Univ, Dept Chem, Shanghai 200433, Peoples R China;[3]Fudan Univ, Adv Mat Lab, Shanghai 200433, Peoples R China

年份：2014

卷号：26

期号：23

起止页码：3912

外文期刊名：ADVANCED MATERIALS

收录：;EI(收录号：20142517847592);WOS:【SCI-EXPANDED(收录号:WOS:000337618600016)】；

基金：This work was supported by NSFC (21173078, 51273064, and 21373084), 973 Project (2013CB733700), The program for Professor of Special Appointment (Eastern Scholar), Innovation Program of Shanghai Municipal Education Commission and Fundamental Research Funds for the Central University.

语种：英文

外文关键词：Addition reactions - Cell signaling - Gelation

摘要：A new concept of photocrosslinking mechanism is developed to construct a 3D cell culture matrix based on a photouncaged-thiol Michael addition. This first-class approach not only provides highly cytocompatible gelation in a spatiotemporally controlled manner, but also controls gel stiffness via appropriate light dose, signaling desired cues to live cells and thus important to bioengineering and regenerative medicine.