文献类型：期刊文献

英文题名：[6]-Gingerol Suppresses Colon Cancer Growth by Targeting Leukotriene A₄ Hydrolase

作者：Jeong, Chul-Ho[1];Bode, Ann M.[1];Pugliese, Angelo[1];Cho, Yong-Yeon[1];Kim, Hong-Gyum[1];Shim, Jung-Hyun[1];Jeon, Young-Jin[1,2];Li, Honglin[3,4];Jiang, Hualiang[3,4];Dong, Zigang[1]

机构：[1]Univ Minnesota, Hormel Inst, Austin, MN 55912 USA;[2]Chosun Univ, Coll Med, Dept Pharmacol, Gwanju, South Korea;[3]Chinese Acad Sci, Drug Discovery & Design Ctr, State Key Lab Drug Res, Shanghai Inst Mat Med, Beijing 100864, Peoples R China;[4]E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China

年份：2009

卷号：69

期号：13

起止页码：5584

外文期刊名：CANCER RESEARCH

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000267691800041)】；

基金：The Hormel Foundation (Austin, MN), Pediatric Pharmaceuticals (Iselin, NJ), Korea Research Foundation Grant (Korean Government, KRF-2007-357-C00084), the 863 Hi-Tech Program of China (grant 2007AA02Z304), and the Shanghai Committee of Science and Technology (Grant 07dz22004).

语种：英文

摘要：[6]-Gingerol, a natural component of ginger, exhibits anti-inflammatory and antitumorigenic activities. Despite its potential efficacy in cancer, the mechanism by which [6]-gingerol exerts its chemopreventive effects remains elusive. The leukotriene A(4) hydrolase (LTA(4)H) protein is regarded as a relevant target for cancer therapy. Our in silico prediction using a reverse-docking approach revealed that LTA(4)H might be a potential target of [6]-gingerol. We supported our prediction by showing that [6]-gingerol suppresses anchorage-independent cancer cell growth by inhibiting LTA(4)H activity in HCT116 colorectal cancer cells. We showed that [6]-gingerol effectively suppressed tumor growth in vivo in nude mice, an effect that was mediated by inhibition of LTA(4)H activity. Collectively, these findings indicate a crucial role of LTA(4)H in cancer and also support the anticancer efficacy of [6]-gingerol targeting of LTA(4)H for the prevention of colorectal cancer. [Cancer Res 2009;69(13):5584-91]