文献类型：期刊文献

英文题名：Highly convergent synthesis of a β-mannuronic acid alginate hexadecasaccharide

作者：Pan, Dingyi[1];Zhang, Liangliang[1];Hua, Qingting[1];Yang, You[1]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2019

卷号：17

期号：25

起止页码：6174

外文期刊名：ORGANIC & BIOMOLECULAR CHEMISTRY

收录：;EI(收录号：20192707126746);WOS:【SCI-EXPANDED(收录号:WOS:000473052800012)】；

基金：Financial support from the Recruitment Program of Global Experts (Y100-4Q-1701, YC0140103), the National Natural Science Foundation of China (21871081) and the Fundamental Research Funds for the Central Universities (50321031916002, 22221818014) is gratefully acknowledged.

语种：英文

摘要：Solution-phase synthesis of poly-beta-mannuronic acids still remains unexplored. We report the first synthesis of a beta-mannuronic acid alginate hexadecasaccharide representing the longest synthetic polymannuronic acid so far. The highly convergent synthetic approach provides a new avenue to access poly-beta-mannuronic acids that can enable the biological evaluation of poly-beta-mannuronic acids as potential therapeutics and vaccines.