文献类型：期刊文献

中文题名：基于瞬时纳米沉淀法制备尺寸可控载药纳米粒子

英文题名：Preparation of Size-Controllable Drug Loaded Nano Particles Based on Flash Nano Precipitation Method

作者：马俊[1];李莉[1];王铭纬[1];周志明[1];郭旭虹[1]

机构：[1]华东理工大学化工学院,上海200237

年份：2017

卷号：43

期号：5

起止页码：597

中文期刊名：华东理工大学学报（自然科学版）

外文期刊名：Journal of East China University of Science and Technology

收录：北大核心:【北大核心2014】；CSCD:【CSCD_E2017_2018】；

基金：国家自然科学基金(21476143)

语种：中文

中文关键词：FNP;聚合物纳米粒子;尺寸可控

外文关键词：FNP ; polymeric nano particles; size-controllable

摘要：合成了5种具有不同分子量、不同亲疏水链段比例的两亲性嵌段共聚物——甲氧基聚乙二醇-b-聚己内酯(mPEG-b-PCL),并以其为表面活性剂,采用瞬时纳米沉淀(Flash Nano Precipitation,FNP)法制备出一系列包裹模型药物β-胡萝卜素的纳米粒子。通过改变两亲性共聚物的结构、分子量、浓度及溶剂体积比(V(H2O)∶V(THF)),成功实现了对纳米粒子尺寸的调控。实验结果表明:聚合物亲水链段分子量比例增大,则纳米粒子尺寸减小;当亲水链段分子量比例相同时,聚合物分子量越大,则纳米粒子尺寸越小;当聚合物质量浓度较高(10.0g/L)时,制备的纳米粒子粒径分布较窄,粒子性能较稳定。
Five amphiphilic diblock copolymers, methoxy poly （ ethylene glycol ） - 6-polycaprolactone （mPEG--PCL ） with different molecular weights and hydrophilic/hydrophobic proportions were synthesized. A series of nano particles encapsulated model drug beta-carotene and protected by the prepared copolymers as surfactants were prepared by using flash nano-precipitation （FNP） method. The size and size distribution of nano particles were controllable by changing the block structure, molecular weight, polymer concentration and solvent ratio （V （H2O） ： V （TH F ） ） . Experimental results showed that the size of nanoparticles decreased by increasing the solvent ratio or hydrophilic proportion. Under the same proportion ofthe hydrophilic moieties,the size of particles was decreased by increasing the molecular weight. The nanoparticles became more stable and their size distribution was narrower upon increasing polymer concentrations.