文献类型：期刊文献

中文题名：抗过敏中草药活性成分的药效评价

英文题名：The Anti-Allergy Effects for Active Constituents Extracted from Chinese Medicinal Herbs

作者：孙启中[1];陶欣艺[1];周勖[1];任宇红[1]

机构：[1]华东理工大学生物反应器工程国家重点实验室,上海200237

年份：2012

卷号：36

期号：6

起止页码：554

中文期刊名：江西师范大学学报（自然科学版）

外文期刊名：Journal of Jiangxi Normal University(Natural Science Edition)

收录：CSTPCD;;北大核心:【北大核心2011】；

基金：国家自然科学基金(21076079)资助项目

语种：中文

中文关键词：中草药;肥大细胞;脱颗粒;组胺;抑制

外文关键词：acnes; Chinese herb; mast cell; degranulation; histamine; mechanism.

摘要：肥大细胞受到抗原刺激后释放组胺是过敏反应的重要过程,对组胺释放的抑制能力是评价抗过敏药物的重要因素.选取多种传统中医记载具有抗过敏作用的中草药,检测了其在体外对肥大细胞脱颗粒并释放组胺的抑制效果.在具有明显效果的中草药中,土茯苓与芍药对于抑制肥大细胞脱颗粒最为突出,IC50分别为62.5μg/mL和113.8μg/mL.土茯苓的突出药效(药物浓度为500μg/mL时抑制率达到95.63%)未曾被报道,具有研究与开发价值.对其机理的初步研究表明蛋白激酶A可能是土茯苓抑制肥大细胞脱颗粒的重要靶点.
Mast cell is considered to be a key actor for the allergic inflammation.Upon presentation of the antigen they could release histamine.The inhibition of histamine releasing is usually used as major element to evaluate the anti-allergy activity of drugs.Diverse herbs which released allergy and inflammation＇ symptom,were selected their depressant effect on mast cells＇ degranulation and the release amount of histamine in vitro were detected.Among the efficient herbs,Glabrous Greenbrier Rhizome and Paeonia Veitchii showed more rejection capability on mast cells＇ degranulation as the IC50 of these two kinds of herb were 62.5 μg/mL and 113.8 μg/mL,respectively.Glabrous Greenbrier Rhizome is worth to be studied due to its conspicuous efficient（the inhibition ratio is 95.63% with the concentration of 500 μg/mL） which has not been reported.The mechanism research suggested that protein kinase A may be one of the target point of Glabrous Greenbrier Rhizome＇s depressant effect on mast cells＇ degranulation.