文献类型：期刊文献

英文题名：Pd-catalyzed Grignard-type reactions

作者：Wei, XF

机构：[1]E China Univ Sci & Technol, Inst Pharmaceut Chem, Shanghai 200237, Peoples R China

年份：2005

卷号：25

期号：2

起止页码：234

外文期刊名：CHINESE JOURNAL OF ORGANIC CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000226796200020)】；

语种：英文

外文关键词：palladium; 1,2-addition; catalysis; C=O bond; C=N bond

摘要：This highlight summarizes the Pd-catalyzed Grignard-type reaction of a C-Pd bond with a C=O or CdropN bond. The Pd-catalyzed reactions between organic halides and C=O or CdropN bonds in the presence or absence of an alkene or alkyne were reviewed. In these intramolecular carbopalladation reactions of C=O or CdropN bonds the reacting carbon-palladium bonds were formed by the oxidative addition of C-X bond to Pd(0), the carbopalladation of an alkene or alkyne, or the nucleopalladation of an alkyne. Intermolecular reactions were observed with the C-Pd bond formed by the C-H activation of the aromatic ring and the nitrile group. The mechanism, in which the regeneration of the catalytically active species is the key step, was also briefly discussed.