文献类型：期刊文献

英文题名：One-pot double [3+2] cycloaddition for diastereoselective synthesis of tetracyclic pyrrolidine compounds

作者：Lu, Qing[1,2];Song, Gonghua[2];Jasinski, Jerry P.[3];Keeley, Amanda C.[3];Zhang, Wei[1]

机构：[1]Univ Massachusetts, Dept Chem, Boston, MA 02125 USA;[2]E China Univ Sci & Technol, Inst Pesticides & Pharmaceut, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China;[3]Keene State Coll, Dept Chem, Keene, NH 03435 USA

年份：2012

卷号：14

期号：11

起止页码：3010

外文期刊名：GREEN CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000310156300009)，CCR-EXPANDED(收录号:WOS:000310156300009)】；

基金：We thank the UMass Boston Center for Green Chemistry for the support of this project. QL thanks the visiting scholarship from China. JPJ acknowledges the NSF-MRI program (grant No. CHE1039027) for funds to purchase the X-ray diffractometer.

语种：英文

摘要：A multicomponent double [3 + 2] cycloaddition reaction of azomethine ylides has been developed for the synthesis of pyrrolidine-fused tetracyclic compounds. This reaction efficiently and stereoselectively generates six bonds and seven chiral centers in a one-pot reaction process.