文献类型：期刊文献

中文题名：生长抑素增强胆囊癌细胞化疗敏感性的研究

英文题名：Study of somatostatin on enhancing chemosensitivity of carcinom a of gdllbladder cells in vitro

作者：李济宇[1];全志伟[1];张强[2];刘建文[2]

机构：[1]上海第二医科大学附属新华医院普外科,上海200092;[2]华东理工大学鲁华生物技术研究所新药药理研究室,上海200237

年份：2004

卷号：9

期号：2

起止页码：171

中文期刊名：中国临床药理学与治疗学

外文期刊名：Chinese Journal of Clinical Pharmacology and Therapeutics

收录：CSTPCD;;CSCD:【CSCD2011_2012】；

语种：中文

中文关键词：生长抑素;阿霉素;化疗敏感性;胆囊癌

外文关键词：somatosta tin; adriamycin; chemosensitivity; carcinoma of gdllbladder cells

摘要：目的 :探讨在生长抑素预先作用下 ,胆囊癌细胞化疗敏感性的变化。方法 :运用生长抑素预先作用于体外培养的人胆囊癌细胞株 ,2 4h后加入梯度浓度的化疗药物阿霉素 ,观察癌细胞的生长曲线 ,并与单独使用化疗药物的癌细胞生长曲线相比较。结果 :阿霉素能够明显抑制胆囊癌细胞的生长 ,其作用呈现效应 -浓度依赖性 (P <0 .0 5)。生长抑素能够诱导离体胆囊癌细胞生长停滞于DNA合成期 (S期)。经生长抑素预处理后 ,阿霉素对癌细胞生长的抑制效果较单独用药为佳 (P <0 .0 1 )。结论 :生长抑素可增强胆囊癌细胞对化疗药物阿霉素的敏感性。
AIM: To explore the change of chemosensitivity of carcinoma of gdllbladder cells after treated with somatostatin. METHODS: Twe nty-four hours after somatostatin given, gradient concentrations of adriamycin were added and growth curve of carcinoma of gdllbladder cells was investigated. The inhibitory effects of adriamycin plus somatostatin and adriamycin alone were compared. RESULTS: Concentration-dependent inhibition of cell growth was shown in carcinoma of gdllbladder cells in adriamycin group ( P< 0.01 ). Somatostatin was found to induce carcinoma of gdllbladder cells growth arrest in DNA-Synthesis phrase, i.e., S phrase . After treated with somatostatin, inhibition of adriamycin was enhanced compare d with that in adriamycin alone group (P< 0.01 ). CON CLUSION: Somatostatin can enhance the chemosensitivity of carcinoma of g dllbladder cells treating with adriamycin.