文献类型：期刊文献

英文题名：Synthesis, physical and mechanical properties of Novel polyurethane based on the poly(1,3-propylene sebacate) and poly(glycerol sebacate)

作者：Zhang, Xian[1,3]; Jiang, Shuai[1,4]; Guo, Jianming[1]; Xin, Zhong[2]

机构：[1] Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China; [2] Shanghai Key Laboratory of Multiphase Materials Chemical Engineering, Department of Product Engineering, East China University of Science and Technology, Shanghai, 200237, China; [3] Shanghai Engineering Research Center of Biliary Tract Minimal Invasive Surgery and Materials, Shanghai, 200032, China; [4] Department of Urology, Zhongshan Hospital Wusong Branch, Fudan University, Shanghai, 200940, China

年份：2025

卷号：32

期号：1

外文期刊名：Journal of Polymer Research

收录：EI(收录号：20245217602470)

语种：英文

外文关键词：Controlled drug delivery - Elastomers - Fibroblasts - Polyurethanes - Shape-memory polymer - Targeted drug delivery

摘要：The stretchable, biodegradable, thermos-responsive, biocompatible and novel poly(1,3-propylene sebacate)-co-poly(glycerol sebacate) polyurethanes (PPGSU), based on poly(glycerol sebacate) (PGS) and poly(1,3-propylene sebacate) (PPS), were synthesized using simple solvent-based two-step method. The comprehensively properties of PPGSU, including the chemical structure, crystalline structure, thermal stability, mechanical performance, water absorption, degradation behavior, drug release behavior, temperature-responsive shape memory effect, as well as biocompatibility were investigated in detail. The impact of the different ratio of PPS and PGS on the properties of final PPGSU product was also studied. The introduction of PPS in the poly(glycerol sebacate urethance) (PGSU) system could increase the glass transition temperature (Tg) and stretchability. The PPGSU polymers showed adjustable tensile strength ranging from 0.5MPa to 1.3MPa, as well as the degradable rate and shape memory effect. Furthermore, these elastomers exhibited promising in vitro biocompatibility with adult mouse fibroblasts L929 cells, indicative of their potential for medical applications. Additionally, the possible potential application of biodegradable PPGSU elastomers in the field of drug delivery were examined. Overall, this research offers new perspectives on the development of biomaterials with tailored properties for medical applications. ? The Polymer Society, Taipei 2024.