文献类型：期刊文献

英文题名：Nervous System-Driven Osseointegration

作者：Sun, Ruoyue[1];Bai, Long[2,3];Yang, Yaru[4];Ding, Yanshu[1];Zhuang, Jingwen[1];Cui, Jingyuan[1,3]

机构：[1]East China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Coll Mat Sci & Engn, Shanghai 200237, Peoples R China;[2]Shanghai Univ, Inst Translat Med, Shanghai 200444, Peoples R China;[3]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Shanghai 200237, Peoples R China;[4]Jiaxing Univ, Coll Mat & Text Engn, Jiaxing 314001, Peoples R China

年份：2022

卷号：23

期号：16

外文期刊名：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000846603300001)】；

基金：This research was funded by the National Natural Science Foundation of China (81901898) and the China Postdoctoral Science Foundation (2019M661404, 2020T130192).

语种：英文

外文关键词：nervous system; neurotrophin; neuropeptide; nerve cell; osseointegration

摘要：Implants are essential therapeutic tools for treating bone fractures and joint replacements. Despite the in-depth study of osseointegration for more than fifty years, poor osseointegration caused by aseptic loosening remains one of the leading causes of late implant failures. Osseointegration is a highly sophisticated and spatiotemporal process in vivo involving the immune response, angiogenesis, and osteogenesis. It has been unraveled that the nervous system plays a pivotal role in skeletal health via manipulating neurotrophins, neuropeptides, and nerve cells. Herein, the research related to nervous system-driven osseointegration was systematically analyzed and reviewed, aiming to demonstrate the prominent role of neuromodulation in osseointegration. Additionally, it is indicated that the implant design considering the role of neuromodulation might be a promising way to prevent aseptic loosening.