文献类型：期刊文献

英文题名：Bio-inspired poly-DL-serine materials resist the foreign-body response

作者：Zhang, Donghui[1];Chen, Qi[2];Bi, Yufang[2];Zhang, Haodong[2];Chen, Minzhang[2];Wan, Jianglin[2];Shi, Chao[2];Zhang, Wenjing[2];Zhang, Junyu[2];Qiao, Zhongqian[2];Li, Jin[3];Chen, Shengfu[4];Liu, Runhui[1,2]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai, Peoples R China;[2]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Res Ctr Biomed Mat,Minist Educ, Sch Mat Sci & Engn,Key Lab Ultrafine Mat, Shanghai, Peoples R China;[3]Shanghai Jiao Tong Univ, Peoples Hosp 9, Shanghai Key Lab Orbital Dis & Ocular Oncol, Dept Ophthalmol,Sch Med, Shanghai, Peoples R China;[4]Zhejiang Univ, Coll Chem & Biol Engn, Key Lab Biomass Chem Engn, Minist Educ, Hangzhou, Zhejiang, Peoples R China

年份：2021

卷号：12

期号：1

外文期刊名：NATURE COMMUNICATIONS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000694655700010)】；

基金：We thank Prof. Aiguo Hu, Dr. Peng Zhao, and Yusen Wu at East China University of Science and Technology for their help on GPC characterization. We thank Prof. Linyong Zhu and Yiqing Zhang at East China University of Science and Technology for their help on compressive strength measurement. The authors also thank the Research Center of Analysis and Test of East China University of Science and Technology for the help on the characterization. Funding: This work was supported by the National Natural Science Foundation of China for Innovative Research Groups (No. 51621002), the National Natural Science Foundation of China (No. 21774031, 31800801), the Natural Science Foundation of Shanghai (18ZR1410300), the National Key Research and Development Program of China (2016YFC1100401), Program of Shanghai Academic/Technology Research Leader (20XD1421400), Research Program of State Key Laboratory of Bioreactor Engineering, the Fundamental Research Funds for the Central Universities.

语种：英文

摘要：Implantation-caused foreign-body response is a commonly encountered issue and can result in failure of implants. Here, the authors demonstrate that a highly water soluble, biocompatible, and easily accessible poly-DL-serine hydrogel can mitigate foreign-body response. Implantation-caused foreign-body response (FBR) is a commonly encountered issue and can result in failure of implants. The high L-serine content in low immunogenic silk sericin, and the high D-serine content as a neurotransmitter together inspire us to prepare poly-DL-serine (PSer) materials in mitigating the FBR. Here we report highly water soluble, biocompatible and easily accessible PSer hydrogels that cause negligible inflammatory response after subcutaneous implantation in mice for 1 week and 2 weeks. No obvious collagen capsulation is found surrounding the PSer hydrogels after 4 weeks, 3 months and 7 months post implantation. Histological analysis on inflammatory cytokines and RNA-seq assay both indicate that PSer hydrogels show low FBR, comparable to the Mock group. The anti-FBR performance of PSer hydrogels at all time points surpass the poly(ethyleneglycol) hydrogels that is widely utilized as bio-inert materials, implying the potent and wide application of PSer materials in implantable biomaterials and biomedical devices.