文献类型：期刊文献

英文题名：Dual-Responsive Ultrathin Peptoid Nanofibers Assembled from Amphiphilic Alternating Peptoids with an Integration of Azobenzene and Histamine Moieties

作者：Ding, Mingyu[1];Jiang, Qianyu[1];Wu, Pengchao[1];Sui, Pengliang[1];Sun, Zichao[1];Yang, Xiaoling[1];Jin, Haibao[1];Lin, Shaoliang[1]

机构：[1]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Sch Mat Sci & Engn, Shanghai Key Lab Adv Polymer Mat, Shanghai 200237, Peoples R China

年份：2025

卷号：26

期号：4

起止页码：2750

外文期刊名：BIOMACROMOLECULES

收录：;EI(收录号：20251418167574);WOS:【SCI-EXPANDED(收录号:WOS:001454573900001)】；

基金：Financial support was provided by the National Natural Science Foundation of China (52373114 and 52325308). The authors thank the Research Center of Analysis and Test of East China University of Science and Technology for the help on the UPLC-MS characterization.

语种：英文

外文关键词：Micelles - Nanoclay - Nanofibers - Photoisomerization - Self assembly

摘要：Ultrathin organic nanofibers (UTONFs) have favorable potential as emerging nanomaterials due to their large aspect ratio, lightweight nature, and mechanical flexibility. Achieving dual stimuli-responsive UTONFs is necessary to satisfy the on-demand requirements of smart and miniature devices but remains challenging. Herein, amphiphilic alternating peptoids (AAPs) modified with azobenzene and histamine groups were successfully synthesized using the solid-phase submonomer synthesis technique. Following subsequent solution self-assembly, photo/CO2 dual-responsive ultrathin peptoid nanofibers (UTPNFs) with a diameter of similar to 1.8 nm and a length of up to several micrometers were generated based on the pendant hydrophobic conjugate stacking mechanism. The photoisomerization of azobenzene was accountable for the reversible transformation from UTPNFs to spherical micelles (similar to 60 nm) under recyclable light irradiation. Owing to the protonation and the resulting electrostatic repulsion interaction, both UTPNFs and spherical micelles displayed a reversible variation in shape and physicochemical properties, including the size, diameter, zeta potential, and pH. Our work offers prospective guidance on the construction of dual-responsive ultrathin organic nanofibers with controllable shape transformation and performance transition.