文献类型：期刊文献

英文题名：Mussel-Inspired Biocompatible PAADOPA/PAAm Hydrogel Adhesive for Amoxicillin Delivery

作者：Xu, Chengyuan[2,3];Chen, Yang[1];Zheng, Zhiyuan[1];Liu, Yongchun[1];Cao, Song[3];Xu, Yisheng[1]

机构：[1]East China Univ Sci & Technol, State Key Lab Chem Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, State Key Lab Chem Engn, Sch Pharm, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Shanghai Key Lab Chem Biol, Sch Pharm, Shanghai 200237, Peoples R China

年份：2020

卷号：59

期号：30

起止页码：13556

外文期刊名：INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH

收录：;EI(收录号：20203509110379);WOS:【SCI-EXPANDED(收录号:WOS:000557853400021)】；

基金：This work was supported by the NSFC grants (21676089, U1932164), International One Belt One Road Collaboration Project of Shanghai (18490740300), Shanghai talent development fund (2017038), the Fundamental Research Funds for the Central Universities (222201717013), the 111 Project of the Ministry of Education of China (no. B08021), and National Key Research and Development Program of China (no. 2017YFD0200505).

语种：英文

外文关键词：Adhesion - Drug products - Molluscs - Targeted drug delivery - Biocompatibility - Hydrogels - Tissue engineering - Body fluids - Controlled drug delivery - Tissue

摘要：The adhesion of drug-loaded hydrogels for topical therapy often drastically deteriorated in humid environments, leading to an ineffective therapeutic concentration. It is necessary to develop a valid strategy for resisting adhesion damage from abundant body fluids and hydrogel detachment from external forces. Herein, we report a mussel-inspired hydrogel adhesive through the introduction of 3,4-dihydroxyphenylalanine (DOPA)-functionalized poly(acrylic acid), named PAADOPA, into polyacrylamide (PAAm) networks. The abundant DOPA moieties endow the PAADOPA/PAAm hydrogel with superior adhesion on various substrates including rough surfaces, smooth surfaces, and tissues. The adhesion strength in the PAADOPA(2.5)/PAAm hydrogel is 3.2 times that of the pure PAAm hydrogel. Most critically, the antiinflammatory drug amoxicillin was successfully encapsulated into the PAADOPA/PAAm hydrogel, demonstrating superior biocompatibility for the sustained release of the drug. Hence, the obtained amoxicillin-loaded PAADOPA/PAAm hydrogel adhesive is shown to have strong adhesion, superior biocompatibility, and sustained release of drugs, providing promising applications in tissue engineering and biomedicinal fields.