文献类型：期刊文献

中文题名：5-(3′-芳基5′-噁唑烷酮基甲氧基)-3(2H)哒嗪酮类化合物的合成及生物活性

英文题名：Synthesis and Biological Activity of 5-(3′-Aryl-2′-oxo-5′-oxazolidinylmethoxy)-3(2H)pyridazinones

作者：曹松[1];宋恭华[1];曲玉成[1];韦娜[1];卢德力[1];黄青春[1]

机构：[1]华东理工大学药物化工研究所

年份：2005

卷号：22

期号：4

起止页码：448

中文期刊名：应用化学

外文期刊名：Chinese Journal of Applied Chemistry

收录：CSTPCD;;北大核心:【北大核心2004】；CSCD:【CSCD2011_2012】；

基金："九七三"国家重点基础研究发展规划项目(2003CB114405);上海市科委攻关项目资助(034319250)

语种：中文

中文关键词：芳基恶唑烷酮基甲氧基哒嗪酮;合成;生物活性

外文关键词：aryloxooxazolidinylmethoxypyridazinone,synthesis,biological activity

摘要：Seven 2-tert-butyl-4-chloro-5-（3′-aryl-2′-oxo-5′-oxazolidinylmethoxy）-3（2H）pyridazinones were synthesized via the reaction of aryl isocyanates and 2-tert-butyl-4-chloro-5-（2,3-epoxypropyloxy）-3（2H）（pyridazinones） prepared by the reaction of 2-tert-butyl-4-chloro-5-hydroxy-3（2H）pyridazinones with epichlorohydrin. The structures of the title compounds were confirmed by 1H NMR, HR MS and IR. The （bioassay） tests showed the inhibition of compound 2b and that of compound 2c against Colletotrichum （lagenarium） under （500 mg/L） were 33% and 50%, respectively.
Seven 2-tert-butyl-4-chloro-5-(3′-aryl-2′-oxo-5′-oxazolidinylmethoxy)-3(2H)pyridazinones were synthesized via the reaction of aryl isocyanates and 2-tert-butyl-4-chloro-5-(2,3-epoxypropyloxy)-3(2H)(pyridazinones) prepared by the reaction of 2-tert-butyl-4-chloro-5-hydroxy-3(2H)pyridazinones with epichlorohydrin. The structures of the title compounds were confirmed by ^(1)H NMR, HR MS and IR. The (bioassay) tests showed the inhibition of compound 2b and that of compound 2c against Colletotrichum (lagenarium) under (500 mg/L) were 33% and 50%, respectively.