文献类型：期刊文献

英文题名：Understanding the Selectivity of a Multichannel Fluorescent Probe for Peroxynitrite Over Hypochlorite

作者：Zhang, Quanjuan[1];Zhang, Na[3];Long, Yi-Tao[3];Qian, Xuhong[1,2];Yang, Youjun[1,2]

机构：[1]E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Meilong Rd 130, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Meilong Rd 130, Shanghai 200237, Peoples R China;[3]E China Univ Sci & Technol, Dept Chem, Meilong Rd 130, Shanghai 200237, Peoples R China

年份：2016

卷号：27

期号：2

起止页码：341

外文期刊名：BIOCONJUGATE CHEMISTRY

收录：;EI(收录号：20220411528690);WOS:【SCI-EXPANDED(收录号:WOS:000370582600009)】；

基金：The work is supported by Shanghai Rising-Star Program (No. 13QA1401200), Doctoral Fund of Ministry of Education of China (No. 20110074120008) and National Natural Science Foundation of China (Nos. 21106043 and 21372080).

语种：英文

外文关键词：Fluorescence - Fluorescence spectroscopy - Nitric oxide

摘要：Peroxynitrite is a prominent biological reactive nitrogen species from radical combination of nitric oxide and superoxide and fundamentally involved in broad spectrum physiological and pathological processes. Though redox-inert itself, peroxynitrite anion (OONO-) attacks various biological electrophiles to generate an array of potent 2-e(-) or 1-e(-) oxidants, which result in cell injuries. Development of fluorescent probes for peroxynitrite, free from interference from hypochlorite, has been an active endeavor of the chemical community. We previously reported a peroxynitrite probe differentiate hypochlorite from peroxynitrite through a multichannel signaling mechanism. Herein, this intriguing selectivity was accounted for through a structure-reactivity relationship study. Also, this work, together with rich literature contributions, has allowed a qualitative guideline in the use of electron-rich aromatic moieties to design probes against peroxynitrite and/or hypochlorite. The viability of this guideline was further testified by development of another list of peroxynitrite selective probes.