文献类型：期刊文献

英文题名：Sustainable sepiolite-based composites for fast clotting and wound healing

作者：Jiang, Yunhong[1];Yang, Yongwen[2,3,5];Peng, Zhangzhe[3,4,5];Li, Yan[6];Peng, Jinfeng[1];Zhang, Yan[3,4,5];Jin, Haibao[7];Tan, Donghui[8];Tao, Lijian[3,4];Ding, Yanhuai[1,8]

机构：[1]Xiangtan Univ, Sch Mech Engn & Mech, Xiangtan 411105, Hunan, Peoples R China;[2]Cent South Univ, Xiangya Hosp, Dept Clin Lab, Changsha 410008, Hunan, Peoples R China;[3]Hunan Key Lab Organ Fibrosis, Changsha 410008, Hunan, Peoples R China;[4]Cent South Univ, Xiangya Hosp, Dept Nephrol, Changsha 410008, Hunan, Peoples R China;[5]Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha 410008, Hunan, Peoples R China;[6]Xiangtan Univ, Int Exchange Sch, Xiangtan 411105, Hunan, Peoples R China;[7]East China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai 200237, Peoples R China;[8]Xiangnan Univ, Key Lab Med Imaging & Artificial Intelligence Huna, Chenzhou 423000, Peoples R China

年份：2023

卷号：149

外文期刊名：BIOMATERIALS ADVANCES

收录：;EI(收录号：20231513881098);WOS:【SCI-EXPANDED(收录号:WOS:001042856000001)】；

基金：Funding This project was supported by Major Program of National Natural Science Foundation of China (82090024) , General Programs of National Natural Science Foundation of China (82173877, 82073918) , Key Research and Development Program of Hunan Province (2021SK2015) , Key Scientific Research Project of Education Department of Hunan Province (22A0113) and Major Science and Technology Projects of Xiangtan Science and Technology Bureau (GX-ZD202210011) .

语种：英文

外文关键词：Hemostatic material; Sepiolite; Sustainability; Antibacterial ability; Carotid artery injury

摘要：Uncontrolled bleeding and bacterial coinfection are the major causes of death after an injury. Fast hemostatic capacity, good biocompatibility, and bacterial coinfection inhibition pose great challenges to hemostatic agent development. A prospective sepiolite/Ag nanoparticles (sepiolite@AgNPs) composite has been prepared by using natural clay sepiolite as template. A tail vein hemorrhage mouse model and a rabbit hemorrhage model were used to evaluate the hemostatic properties of the composite. The sepiolite@AgNPs composite can quickly absorb fluid to subsequently stop bleeding due to the natural fibrous crystal structure of sepiolite, and inhibit bacterial growth with the antibacterial ability of AgNPs. Compared with commercially-available zeolite material, the as -prepared composite exhibits competitive hemostatic properties without exothermic reaction in the rabbit model of femoral and carotid artery injury. The rapid hemostatic effect was due to the efficient absorption of eryth-rocyte and activation of the coagulation cascade factors and platelets. Besides, after heat-treatment, the com-posites can be recycled without significant reduction of hemostatic performance. Our results also prove that sepiolite@AgNPs nanocomposites can stimulate wound healing. The sustainability, lower-cost, higher bioavailability, and stronger hemostatic efficacy of sepiolite@AgNPs composite render these nanocomposites as more favorable hemostatic agents for hemostasis and wound healing.