文献类型：期刊文献

英文题名：Plant defense metabolites influence the interaction between an insect herbivore and an entomovirus

作者：Wang, Jin-Yan[1];Fan, Neng-Neng[1];Yuan, Yuan;Bass, Chris[3];Siemann, Evan[4];Ji, Xiang-Yun[1];Jiang, Jie-Xian[1];Wan, Nian-Feng[1,2]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Key Lab Low Carbon Green Agr South Eastern China, Shanghai Key Lab Chem Biol,Ecoenvironm Protect Ins, Shanghai 201403, Peoples R China;[2]East China Univ Sci & Technol, Inst Pesticides & Pharmaceut, Shanghai 200237, Peoples R China;[3]Univ Exeter, Ctr Ecol & Conservat, Penryn TR10 9WT, Cornwall, England;[4]Rice Univ, Dept BioSci, Houston, TX 77005 USA

年份：2024

卷号：34

期号：24

起止页码：5758

外文期刊名：CURRENT BIOLOGY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001407065500001)】；

基金：We thank Prof. Ted C.J. Turlings at University of Neuchatel and Dr. Mingbo Yin at Fudan University for providing us with constructive suggestions. This study was sponsored by Shanghai Sailing Program (grant no. 21YF1441100) , Na-tional Natural Science Foundation of China (grant no. 31672083) , SAAS

语种：英文

外文关键词：Highlights; Plant secondary metabolites (PSMs) affect caterpillars'; plant phenolics

摘要：The tri-trophic interaction of plants, insect herbivores, and entomoviruses is an important topic in ecology and pest control. The susceptibility of insect herbivores to entomoviruses (e.g., nucleopolyhedroviruses) is influenced by host plants; however, the role of plant secondary metabolites in determining such susceptibility is poorly understood. Metabolomic analyses of Brassica oleracea, Glycine max, and Ipomoea aquatica plants, which differ in how they affect the susceptibility of Spodoptera exigua to nucleopolyhedroviruses among 14 plants, suggested that the plant secondary metabolites genistein, kaempferol, quercitrin, and coumarin play a role in influencing nucleopolyhedroviruses susceptibility. Subsequently, transcriptomic analysis of caterpillars, treated with nucleopolyhedroviruses alone or with one of these four phenolics, identified four genes (CYP340K4, CXE18, GSTe, and GSTe1) that were significantly downregulated by the phenolics. Functional characterization of these genes suggested that their downregulation significantly increased larval sensitivity to nucleopolyhedroviruses and altered aspects of the immune response. Our findings provide new insight into the role of plant defense metabolites in influencing the interactions between insect herbivores and entomopathogens and identify plant secondary metabolites as potential synergists of viral agents for the control of agricultural pests.