文献类型：期刊文献

英文题名：Rhodium(iii)-catalyzed C4-amidation of indole-oximes with dioxazolonesviaC-H activation

作者：Tang, Shi-Biao[1];Fu, Xiao-Pan[1];Wu, Gao-Rong[1];Zhang, Li-Li[1];Deng, Ke-Zuan[1];Yang, Jin-Yue[1];Xia, Cheng-Cai[2];Ji, Ya-Fei[1]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Minist Educ, Engn Res Ctr Pharmaceut Proc Chem, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]Shandong First Med Univ & Shandong Acad Med Sci, Pharm Coll, 619 Changcheng Rd, Tai An 271016, Shandong, Peoples R China

年份：2020

卷号：18

期号：39

起止页码：7922

外文期刊名：ORGANIC & BIOMOLECULAR CHEMISTRY

收录：;EI(收录号：20204409428915);WOS:【SCI-EXPANDED(收录号:WOS:000579572100023)，CCR-EXPANDED(收录号:WOS:000579572100023)】；

基金：We gratefully thank the National Natural Science Foundation of China (Project no. 21676088) for financial support.

语种：英文

外文关键词：Activation analysis - Polycyclic aromatic hydrocarbons - Rhodium compounds

摘要：A novel method for the Rh(iii)-catalyzed oxime-directed C-H amidation of indoles with dioxazolones has been developed. This strategy provides an exclusive site selectivity and the directing group can be easily removed. This transformation features a wide substrate scope, good functional group tolerance and excellent yields, and may serve as a significant tool to construct structurally diverse indole derivatives for the screening of potential pharmaceuticals in the future.