文献类型：期刊文献

英文题名：Enantioselective Organocatalytic Michael Addition of Malonates to α,β-Unsaturated Ketones

作者：Li, Pengfei[1,2];Wen, Shigang[2];Yu, Feng[2];Liu, Qiaoxia[2];Li, Wenjun[2];Wang, Yongcan[1];Liang, Xinmiao[1,2];Ye, Jinxing[2]

机构：[1]Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China;[2]E China Univ Sci & Technol, Minist Educ, Engn Res Ctr Pharmaceut Proc Chem, Shanghai 200237, Peoples R China

年份：2009

卷号：11

期号：3

起止页码：753

外文期刊名：ORGANIC LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000262913500065)，CCR-EXPANDED(收录号:WOS:000262913500065)】；

基金：This work was sponsored by the start-up fund from East China University of Science and Technology and Shanghai Pujiang Program (08PJ1403300).

语种：英文

摘要：A novel type of primary amine thiourea organocatalysts derived from 1,2-diaminocyclohexane and 9-amino (9-deoxy) cinchona alkaloid was developed into asymmetric Michael addition of malonates to enones. A series of cyclic and acyclic enones could react very well with different malonates in the presence of 4 with 0.5-10 mol % catalyst loading affording chiral Michael adducts with excellent yields and ee values.