文献类型：期刊文献

英文题名：Novel Axially Chiral Ligand-Enabled Copper-Catalyzed Asymmetric Oxidative Coupling of 2-Naphthols for the Synthesis of 6,6′-Disubstituted BINOLs

作者：Wang, Pengyang[1,2];Cen, Shouyi[1,2];Gao, Jun[1,2];Shen, Ahui[1,2];Zhang, Zhipeng[1,2]

机构：[1]East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Frontiers Sci Ctr Materiobiol & Dynam Chem, Sch Chem & Mol Engn,Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Frontiers Sci Ctr Materiobiol & Dynam Chem, Sch Chem & Mol Engn,Joint Int Res Lab Precis Chem, Shanghai 200237, Peoples R China

年份：2022

卷号：24

期号：12

起止页码：2321

外文期刊名：ORGANIC LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000780673100010)，CCR-EXPANDED(收录号:WOS:000780673100010)】；

基金：We thank the Research Center of Analysis and Test, East China University of Science and Technology for the help with the characterization and Prof. Yifeng Chen (ECUST) for sharing the instruments. This work was supported by the National Natural Science Foundation of China (21702059) , Shanghai Pujiang Program (18PJ1402200) , Fundamental Research Funds for the Central Universities (222201814014, JKVJ1211010, JKVJ12001010) , Shanghai Municipal Science and Technology Major Project (2018SHZDZX03) , Program of Introducing Talents of Discipline to Universities (B16017) , and "Thousand Plan" Youth program.

语种：英文

摘要：Novel axially chiral ligands have been designed and synthesized by merging the chelating picolinic acid with substituted BINOLs. The in-situ-prepared copper catalysts from the ligands and CuI enable the asymmetric oxidative coupling of 2-naphthols, affording 6,6'-disubstituted BINOLs in up to 89% yield with good enantioselectivities (up to 96:4 e.r.).