文献类型：期刊文献

英文题名：Preparation and pharmaceutical/pharmacodynamic evaluation of topical brucine-loaded liposomal hydrogel

作者：Wang, Junling[1,2];Yuan, Yuan[1,2];Liu, Changsheng[1,2];Zhu, Di[3];Shen, Xi[1,2];Yang, Baican[3]

机构：[1]E China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Engn Res Ctr Biomed Mat, Minist Educ, Shanghai 200237, Peoples R China;[3]Shanghai Univ Tradit Chinese Med, Pharm Dept Tradit Chinese Med, Shanghai 201203, Peoples R China

年份：2009

卷号：20

期号：10

起止页码：2075

外文期刊名：JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE

收录：;EI(收录号：20094112366210);WOS:【SCI-EXPANDED(收录号:WOS:000270201100012)】；

基金：The authors acknowledge the financial support from Shanghai Nanotechnology Special Foundation ( No 0552nm007, 0852nm05300) and Novel medicine foundation of Shanghai Science and Technology Commission ( 08DZ1972105).

语种：英文

外文关键词：Liposomes - Diseases - Drug delivery

摘要：To reduce the toxicity and enhance the therapeutic efficacy of brucine, a traditional Chinese medicine for relieving arthritic and traumatic pain, in this study, a novel brucine-loaded liposomal hydrogel (BLH) formulation, suitable for topical application, was developed. Spherical liposomes composed of lecithin and cholesterol, with brucine, was prepared by a modified ethanol-dripping method. High percentage (over 80%) of encapsulated brucine in liposomes was obtained. Topical liposomal hydrogel formulations were prepared by further incorporation of the prepared liposomes into structured carbopol 940 hydrogels with the concentration of carbopol 1.0%, the ratio of glycerol to carbopol 8:1 and the brucine content 0.1%. The liposomal hydrogel formulations provided an obvious promotion for skin permeation of bruicne while for the free brucine in hydrogels (BH), there was no detectable drug permeation through the skin. The safety evaluation showed that the prepared BLH were no irritation to both the broken and integrity skin. Pharmacodynamic evaluation revealed that the BLH showed a better therapeutic efficacy than that of the BH. So, it can be concluded that the BLH developed here could represent a safe, effective and promising transdermal formulation for local treatment of analgesic and anti-inflammatory disease.