文献类型：期刊文献

英文题名：Microfluidic-Assisted Self-Assembly of Molecular Hydrogelator at Water-Water Interfaces for Continuous Fabrication of Supramolecular Microcapsules

作者：Li, Zhongqi[1];Wang, Hucheng[1];Gao, Yuliang[1];Chen, Jingjing[1];Gu, Guanyao[1];Liu, Jing[1];Chen, Yuqian[1];Guo, Xuhong[1];Wang, Yiming[1,2]

机构：[1]East China Univ Sci & Technol, State Key Lab Chem Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Shanghai Key Lab Intelligent Sensing & Detect Tech, Shanghai 200237, Peoples R China

年份：2024

卷号：20

期号：45

外文期刊名：SMALL

收录：;EI(收录号：20243016764882);WOS:【SCI-EXPANDED(收录号:WOS:001275642600001)】；

基金：The authors acknowledge the financial support of the Natural Science Foundation of China (21908061), the Shanghai Pilot Program for Basic Research (22TQ1400100-9), the "Chenguang Program" supported by the Shanghai Education Development Foundation and Shanghai Municipal Education Commission (20CG36), the National Key Research and Development Program of China (2022YFD70050101), the Natural Science Foundation of Shanghai (22ZR1417700), and the Open Project of State Key Laboratory of Chemical Engineering (SKL-ChE-23C01) Fundamental Research Funds for the Central Universities.

语种：英文

外文关键词：directed self-assembly; hydrogels; microcapsules; microfluidics; supramolecular chemistry

摘要：Control over the self-assembly of small molecules at specific areas is of great interest for many high-tech applications, yet remains a formidable challenge. Here, how the self-assembly of hydrazone-based molecular hydrogelators can be specifically triggered at water-water interfaces for the continuous fabrication of supramolecular microcapsules by virtue of the microfluidic technique is demonstrated. The non-assembling hydrazide- and aldehyde-based hydrogelator precursors are distributed in two immiscible aqueous polymer solutions, respectively, through spontaneous phase separation. In the presence of catalysts, hydrazone-based hydrogelators rapidly form and self-assemble into hydrogel networks at the generated water-water interfaces. Relying on the microfluidic technique, microcapsules bearing a shell of supramolecular hydrogel are continuously produced. The obtained microcapsules can effectively load enzymes, enabling localized enzymatic growth of supramolecular fibrous supramolecular structures, reminiscent of the self-assembly of biological filaments within living cells. This work may contribute to the development of biomimetic supramolecular carriers for applications in biomedicine and fundamental research, for instance, the construction of protocells. This work reports access to localized self-assembly of molecular hydrogelator at water-water interfaces for microfluidic-assisted continuous fabrication of supramolecular microcapsules in an all-aqueous environment using the microfluidic technique. These microcapsules can serve as biomimetic carriers to load enzymes, enabling enzymatic growth of supramolecular fibers within their cavities resembling the growth of biological filaments in living cells. image