文献类型：期刊文献

英文题名：Growth of boron-rich supramolecular polymers inside cancer cells through organocatalysis-mediated self-assembly

作者：Wei, Lai[1];Gao, Yuliang[1];Lin, Kehong[1];Guo, Xuhong[1];Wang, Yiming[1,2]

机构：[1]East China Univ Sci & Technol, Sch Chem Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Shanghai Key Lab Intelligent Sensing & Detect Tech, Shanghai, Peoples R China

年份：2026

外文期刊名：POLYMER CHEMISTRY

收录：;EI(收录号：20263421344339);Scopus(收录号：2-s2.0-105048012565);WOS:【SCI-EXPANDED(收录号:WOS:001854579600001)】；

基金：We acknowledge the financial support of Shanghai Pilot Program for Basic Research (22TQ1400100-9), National Key Research and Development Program of China (2022YFD70050101), and the Fundamental Research Funds for the Central Universities.

语种：英文

外文关键词：Boron - Cancer cells - Cells - Cytology - Diseases - Radiotherapy - Self assembly

摘要：Boron neutron capture therapy (BNCT) has emerged as a precise and safe radiotherapy technique for the treatment of cancers. To achieve ideal radiotherapy effects, the major hurdle lies in the enrichment of boron in cancer cells. Here, a strategy of organocatalysis-mediated intracellular growth of supramolecular polymers for the accumulation of boron in cancer cells is described. The involved organocatalyst can accelerate the intracellular formation and self-assembly of boron-containing monomers, generating boron-rich supramolecular polymers in cancer cells that lead to 2.4 times higher boron content than in the non-assembling case. This work would accelerate the exploitation of new boron delivery methods for high-efficiency BNCT.