文献类型：期刊文献

英文题名：Cationic poly(ε-caprolactone) surface functionalized mesoporous silica nanoparticles and their application in drug delivery

作者：Zhang, Yan[1,2];Wang, Zhaojun[1];Zhou, Weimin[2];Min, Guoquan[2];Lang, Meidong[1]

机构：[1]E China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Sch Mat Sci & Engn, Shanghai 200237, Peoples R China;[2]Shanghai Nanotechnol Promot Ctr, Shanghai 200237, Peoples R China

年份：2013

卷号：276

起止页码：769

外文期刊名：APPLIED SURFACE SCIENCE

收录：;EI(收录号：20132016327958);WOS:【SCI-EXPANDED(收录号:WOS:000318979800110)】；

基金：Financial support from the National Natural Science Foundation of China (20804015), the Fundamental Research Funds for the Central Universities (WD0913008 and WD1014036), and Shanghai Key Laboratory Project (08DZ2230500) are gratefully acknowledged.

语种：英文

外文关键词：Hollow mesoporous silica; Surface modification; Cationic; Poly(epsilon-caprolactone)

摘要：Cationic poly(epsilon-caprolactone) modified hollow mesoporous silica (HMSNs) was achieved by a post graft method via covalent linkage between the silanols on the surface of silica and the trimethoxysilane groups at the end of the poly(gamma-(carbamic acid benzyl ester)-epsilon-caprolactone). The trimethoxysilane groups were introduced to poly(gamma-(carbamic acid benzyl ester)-epsilon-caprolactone) by ring opening polymerization of gamma-(carbamic acid benzyl ester)-epsilon-caprolactone (gamma CAB epsilon CL) with 3-aminopropyl trimethoxysilane as initiator. Subsequently, the polymer was grafted to the HMSNs and the protected groups of Cbz were removed, thus the amino groups were obtained accordingly. The structure of the polymer was confirmed by H-1 NMR. In addition, the TEM and SEM demonstrated that the HMSNs were spherical and the polymer was well coated on the spheres. FTIR, TGA and N-2 adsorption results proved that the modified processes were effective and the structure of the HMSNs was well reserved. The cationic surface was further confirmed by zeta potential. Moreover, the potential application of the HMSNs in drug delivery was studied with ammonium glycyrrhizinate (AMG) as model drug. Results showed that the cationic HMSNs could be an efficient AMG carrier. (c) 2013 Elsevier B.V. All rights reserved.