文献类型：期刊文献

英文题名：Enhancing Cell Nucleus Accumulation and DNA Cleavage Activity of Anti-Cancer Drug via Graphene Quantum Dots

作者：Wang, Chong[1];Wu, Congyu[2];Zhou, Xuejiao[2];Han, Ting[2];Xin, Xiaozhen[1];Wu, Jiaying[1];Zhang, Jingyan[1];Guo, Shouwu[2]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]Shanghai Jiao Tong Univ, Res Inst Micro Nano Sci & Technol, Key Lab Thin Film & Microfabricat, Minist Educ, Shanghai 200240, Peoples R China

年份：2013

卷号：3

外文期刊名：SCIENTIFIC REPORTS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000325215600002)】；

基金：This research was carried out with financial support from the National Science foundation of China (Nos. 91123011, 90923041, and 31070742), the state key laboratory of bioreactor engineering (No. 2060204), 111 Project (No. B07023), the Shanghai Committee of Science and Technology (Nos. 11DZ2260600 and 12nm0503500), and National "973 program" (No. 20101CB933900) and "863 program" (No. 2012AA022603) of China.

语种：英文

摘要：Graphene quantum dots (GQDs) maintain the intrinsic layered structural motif of graphene but with smaller lateral size and abundant periphery carboxylic groups, and are more compatible with biological system, thus are promising nanomaterials for therapeutic applications. Here we show that GQDs have a superb ability in drug delivery and anti-cancer activity boost without any pre-modification due to their unique structural properties. They could efficiently deliver doxorubicin (DOX) to the nucleus through DOX/GQD conjugates, because the conjugates assume different cellular and nuclear internalization pathways comparing to free DOX. Also, the conjugates could enhance DNA cleavage activity of DOX markedly. This enhancement combining with efficient nuclear delivery improved cytotoxicity of DOX dramatically. Furthermore, the DOX/GQD conjugates could also increase the nuclear uptake and cytotoxicity of DOX to drug-resistant cancer cells indicating that the conjugates may be capable to increase chemotherapy efficacy of anti-cancer drugs that are suboptimal due to the drug resistance.