文献类型：期刊文献

英文题名：Neojaponicone A, a bioactive sesquiterpene lactone dimer with an unprecedented carbon skeleton from Inula japonica

作者：Qin, Jiang Jiang[1];Wang, Li Yan[2];Zhu, Jia Xian[1];Jin, Hui Zi[1];Fu, Jian Jun[1];Liu, Xiao Feng[2];Li, Hong Lin[2];Zhang, Wei Dong[1,3]

机构：[1]Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200240, Peoples R China;[2]E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China;[3]Second Mil Med Univ, Dept Phytochem, Sch Pharm, Shanghai 200433, Peoples R China

年份：2011

卷号：47

期号：4

起止页码：1222

外文期刊名：CHEMICAL COMMUNICATIONS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000286055700028)】；

基金：The work was supported by NSFC (30725045), the Special Program for New Drug Innovation of the Ministry of Science and Technology, China (2009ZX09311-001, 2008ZX09101-Z-029, 2009ZX09103-375), National comprehensive technology platforms for innovative drug R&D, 2009ZX09301-007, Shanghai Leading Academic Discipline Project (B906), and in part by the Scientific Foundation of Shanghai Committee of Science and Technology (08DZ1971302, 09DZ1975700, 09DZ1971500, 09DZ1972200).

语种：英文

摘要：Five new dimeric sesquiterpene lactones, neojaponicone A (1) and japonicones M-P (2-5) were isolated from the aerial part of Inula japonica. Neojaponicone A (1) has an unprecedented carbon skeleton with an unusual valerolactone system formed between a guaianolide and an eudesmane. The structure and absolute configuration of 1 were established by extensive analysis of spectroscopic data and computational approaches.