文献类型：期刊文献

英文题名：TfOH-Catalyzed Cascade Reaction: Metal-Free Access to 3,3-Disubstituted Phthalides from o-Alkynylbenzoic Acids

作者：Zhang, Yanqiu[1];Zhang, Zhiliang[1];Xia, Yunxin[1];Wang, Jiayi[1];Peng, Yanqing[1];Song, Gonghua[1]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China

年份：2023

卷号：88

期号：18

起止页码：12924

外文期刊名：JOURNAL OF ORGANIC CHEMISTRY

收录：;EI(收录号：20233814758957);WOS:【SCI-EXPANDED(收录号:WOS:001190499800001)，CCR-EXPANDED(收录号:WOS:001190499800001)】；

基金：Financialsupport for this study from the National Key Researchand Development Plan (grant no. 2017YFD0200504) is gratefully acknowledged.

语种：英文

外文关键词：Cyclization - Regioselectivity

摘要：A facile new method for the synthesis of 3,3-disubstituted phthalides is reported. A successive reaction process begins with the TfOH-catalyzed cyclization of o-alkynylbenzoic acids followed by an ortho-regioselective electrophilic alkylation of various electron-rich aromatic compounds or alkenes, which has been successfully developed. The corresponding regioselective products of 3-substituted phthalide were obtained in good to high yields.