文献类型：期刊文献

英文题名：Construction of adjacent spiro-quaternary and tertiary stereocenters through phosphine-catalyzed asymmetric [3+2] annulation of allenoates with alkylidene azlactones

作者：Wang, De[1,2];Wei, Yin[3];Shi, Min[1,2,3]

机构：[1]E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China;[3]Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

年份：2012

卷号：48

期号：22

起止页码：2764

外文期刊名：CHEMICAL COMMUNICATIONS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000300312600007)，CCR-EXPANDED(收录号:WOS:000300312600007)】；

基金：Financial support from the Shanghai Municipal Committee of Science and Technology (11JC1402600), the National Basic Research Program of China (973)-2010CB833302, the Fundamental Research Funds for the Central Universities and the National Natural Science Foundation of China for financial support (20902019, 20872162, 20672127, 20821002, 20732008, 20772030 and 20702059) is greatly acknowledged. We especially thank Prof. Qi-Lin, Zhou and Dr Shou-Fei Zhu from Nankai University for providing the chiral phosphine.

语种：英文

摘要：A novel axially chiral spiro-phosphine-catalyzed highly regio-, diastereo- and enantioselective [3 + 2] cycloaddition of alkylidene azlactones with various allenic esters has been developed, affording the corresponding functionalized spirocyclic products in moderate to excellent yields under mild conditions. These spirocyclic products as masked amino acids can be easily transformed into aspartic amino acid analogues.