文献类型：期刊文献

英文题名：Confined Chiral Pd(II) Catalyst-Enabled Enantioselective Intramolecular Aminoalkylation of Alkenes: One-Step Construction of Chiral N-Fused Bicyclic Skeletons

作者：Chen, Yayun[1,2];Ma, Sijia[1,2];Li, Chuanliang[1,2];Cen, Shouyi[1,2];Zhang, Zhipeng[1,2]

机构：[1]East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Frontiers Sci Ctr Materiobiol & Dynam Chem, Sch Chem & Mol Engn,KeyLab Adv Mat, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Frontiers Sci Ctr Materiobiol & Dynam Chem, Sch Chem & Mol Engn,Joint Int Res Lab Precis Chem, Shanghai 200237, Peoples R China

年份：2026

卷号：148

期号：5

起止页码：5347

外文期刊名：JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001669766700001)】；

基金：We thank the Research Center of Analysis and Test, East China University of Science and Technology for the help with the characterization. We thank Prof. Yuan-Yuan Zhu (HFUT) for the help with the single crystal X-ray diffraction and structure analysis. We acknowledge the National Natural Science Foundation of China (22371072), Natural Science Foundation of Shanghai (24ZR1415000), Fundamental Research Funds for the Central Universities (222201717003, JKVJ1251010, SLJ13233303 and YJ0142232), Science and Technology Commission of Shanghai Municipality (24DX1400200), Program of Introducing Talents of Discipline to Universities (B16017), and Shanghai Postdoctoral Excellence Program (2022145) for their generous financial support.

语种：英文

摘要：Highly enantioselective intramolecular aminoalkylation of unactivated alkenes has been accomplished for the first time through the development of a novel category of confined chiral Pd(II) catalysts consisting of two axially chiral picolinic acid ligands. A variety of polycyclic compounds, featuring a saturated chiral N-fused 6/5 or 7/5 bicyclic skeleton, were synthesized in moderate to good yields with excellent enantiomeric ratios (up to 99.5:0.5) through the formation of both a C-N bond and a C-C bond in a single synthetic step.